INT184694

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.55
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.27
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Usf1) enzyme binding (Usf1) DNA binding (Usf1)
Anatomy Link Frequency
neuronal 1
Usf1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 3 97.32 Very High Very High Very High
Inflammation 159 96.64 Very High Very High Very High
substance P 44 92.36 High High
gABA 1 64.56 Quite High
Inflammatory response 18 49.40 Quite Low
Kinase C 37 45.00 Quite Low
Hippocampus 63 40.08 Quite Low
Central nervous system 21 39.12 Quite Low
Arthritis 2 12.80 Low Low
depression 9 5.36 Low Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 12 100.00 Very High Very High Very High
INFLAMMATION 186 96.64 Very High Very High Very High
Overactive Bladder 136 96.48 Very High Very High Very High
Cancer 61 90.72 High High
Diabetes Mellitus 10 89.60 High High
Small Cell Lung Carcinoma 3 88.96 High High
Hyponatremia 15 86.36 High High
Disseminated Intravascular Coagulation 4 82.64 Quite High
Bladder Cancer 12 79.28 Quite High
Cystitis 34 73.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the ten genes assayed, the expression changes for eight genes were confirmed with a change of 1.3-fold or greater: intracisternal-A particles (Iap), upstream transcription factor 1 (Usf1), potassium voltage-gated channel, subfamily Q, member 2 (Kcnq2), chemokine (C-C motif) ligand 19 (Ccl19), erythroid differentiation regulator (edr), caspase 9 (Casp9), chemokine (C-C motif) ligand 27 (Ccl27), complement and component 4 (C4).
Gene_expression (expression) of Usf1 associated with chemokine
1) Confidence 0.55 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 0.10 Pain Relevance 0.13
USF1/USF2
Gene_expression (/) of USF1
2) Confidence 0.32 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.41 Pain Relevance 0
USF1/USF2, which is a basic-helix-loop-helix (bHLH) transcription factor, is ubiquitously present in a broad range of cells (Sirito et al. 1994).
Gene_expression (present) of USF1
3) Confidence 0.28 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.51 Pain Relevance 0
In conclusion, the mucosa regulatory network presents USF in a central position raising the hypothesis that USF-target promoters such as the TGF-?
Gene_expression (presents) of USF
4) Confidence 0.26 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.78 Pain Relevance 0.09
In conclusion, the mucosa regulatory network presents USF in a central position raising the hypothesis that USF-target promoters such as the TGF-?
Gene_expression (promoters) of USF-target
5) Confidence 0.26 Published 2006 Journal BMC Physiol Section Body Doc Link PMC1382248 Disease Relevance 0.81 Pain Relevance 0.09
Another TRE over-expressed in the NK1R-dependent cluster was the upstream stimulatory factor (USF).
Gene_expression (expressed) of USF
6) Confidence 0.24 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.48 Pain Relevance 0.21
Although widely expressed, USF can mediate tissue-specific transcripts.
Gene_expression (expressed) of USF
7) Confidence 0.22 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.46 Pain Relevance 0.20
USF1/USF2 is not a determinant which facilitates the vasopressin gene expression in the SCLC cells in particular, and not other non-neuronal cells, because these transcription factors are ubiquitously expressed.
Gene_expression (expressed) of USF1 in neuronal associated with small cell lung cancer
8) Confidence 0.14 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.48 Pain Relevance 0
In the coding region, putative regulatory factors include AHR/ARNT, USF, ELK1, HSF1, HSF2, ARP1, RFX1, GATA1, AP4, E2F, and ARP1.
Gene_expression (include) of USF
9) Confidence 0.05 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.13 Pain Relevance 0
Putative binding sites for several known transcription factors, namely Sp1, E2F, CdxA, GATA, c-Ets, HSF2, Ik2, USF and SRY are found in the upstream region [28].
Gene_expression (found) of USF
10) Confidence 0.02 Published 2008 Journal Current Genomics Section Body Doc Link PMC2691673 Disease Relevance 0.11 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox