INT184696

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 13.60
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Xbp1) DNA binding (Xbp1)
Anatomy Link Frequency
SH-SY5Y 1
retina 1
proximal 1
ganglion 1
Xbp1 (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 11 97.62 Very High Very High Very High
Glutamate receptor 5 91.72 High High
Glutamate 10 86.52 High High
Neurotransmitter 6 84.36 Quite High
excitatory amino acid 10 83.16 Quite High
Hippocampus 96 71.12 Quite High
Inflammation 78 54.72 Quite High
nMDA receptor 10 54.08 Quite High
addiction 2 50.00 Quite Low
Central nervous system 10 46.16 Quite Low
Disease Link Frequency Relevance Heat
Stress 404 100.00 Very High Very High Very High
Shock 166 100.00 Very High Very High Very High
Ganglion Cysts 122 99.52 Very High Very High Very High
Aging 203 99.44 Very High Very High Very High
Death 163 99.16 Very High Very High Very High
Apoptosis 66 98.72 Very High Very High Very High
Sprains And Strains 259 98.06 Very High Very High Very High
Targeted Disruption 52 96.96 Very High Very High Very High
Disease 51 90.80 High High
Atherosclerosis 106 85.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Accumulation of unfolded proteins in the ER activates the unfolded protein response (UPR), resulting in transcriptional induction of ER chaperones and proteases in part through activation of XBP1.
Positive_regulation (activation) of XBP1
1) Confidence 0.60 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.83 Pain Relevance 0
They demonstrated to be caused by an accumulation of polyubiquitinated proteins and increases in X box binding protein (XBP-1) mRNA splicing and C/EBP-homologous (CHOP) mRNA, representing activation of the unfolded-protein response (UPR) signaling pathway.
Positive_regulation (accumulation) of X box binding protein
2) Confidence 0.57 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.84 Pain Relevance 0.28
The two strains demonstrating accelerated aging, S8 and S10, shared many differences relative to SR1, including increased expression levels of stress-response genes such as those for the heat-shock proteins Hsp70-1 and Hspa5, and for X-box binding protein 1 (Xbp1).
Positive_regulation (increased) of X-box binding protein 1 associated with stress, aging, shock and sprains and strains
3) Confidence 0.47 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.81 Pain Relevance 0.06
The two strains demonstrating accelerated aging, S8 and S10, shared many differences relative to SR1, including increased expression levels of stress-response genes such as those for the heat-shock proteins Hsp70-1 and Hspa5, and for X-box binding protein 1 (Xbp1).
Positive_regulation (increased) of Xbp1 associated with stress, aging, shock and sprains and strains
4) Confidence 0.47 Published 2005 Journal Genome Biol Section Body Doc Link PMC1175968 Disease Relevance 1.81 Pain Relevance 0.06
Together, these results suggest that XBP-1 splicing, representing activation of the ER-stress signal pathway, may be induced in retinal ganglion and amacrine and microglia cells during the early stages of retinal cell damage.


Positive_regulation (induced) of XBP-1 in ganglion associated with ganglion cysts and stress
5) Confidence 0.41 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.51 Pain Relevance 0
Increase in XBP-1-venus fusion protein in the retina in ER stress-activated indicator (ERAI)-transgenic mice
Positive_regulation (Increase) of XBP-1 in retina associated with targeted disruption and stress
6) Confidence 0.41 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.19 Pain Relevance 0
They demonstrated to be caused by an accumulation of polyubiquitinated proteins and increases in X box binding protein (XBP-1) mRNA splicing and C/EBP-homologous (CHOP) mRNA, representing activation of the unfolded-protein response (UPR) signaling pathway.
Positive_regulation (increases) of XBP-1
7) Confidence 0.38 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.76 Pain Relevance 0.27
They demonstrated to be caused by an accumulation of polyubiquitinated proteins and increases in X box binding protein (XBP-1) mRNA splicing and C/EBP-homologous (CHOP) mRNA, representing activation of the unfolded-protein response (UPR) signaling pathway.
Positive_regulation (accumulation) of XBP-1
8) Confidence 0.38 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.84 Pain Relevance 0.28
Some representative examples include proinflammatory genes such as Interleukin 8 (IL-8) and chemokine (C-X-C motif) ligand 1 (CXCL1) production, immune response genes such as Interleukin 11 (IL-11) and UPR genes such as activating transcription factor 4 (ATF 4), heat shock 70 kDa protein 8 (HSPA8) and X-box binding protein 1 (XBP1).
Positive_regulation (activating) of X-box binding protein 1 associated with chemokine and shock
9) Confidence 0.31 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2761850 Disease Relevance 0.36 Pain Relevance 0.05
Some representative examples include proinflammatory genes such as Interleukin 8 (IL-8) and chemokine (C-X-C motif) ligand 1 (CXCL1) production, immune response genes such as Interleukin 11 (IL-11) and UPR genes such as activating transcription factor 4 (ATF 4), heat shock 70 kDa protein 8 (HSPA8) and X-box binding protein 1 (XBP1).
Positive_regulation (activating) of XBP1 associated with chemokine and shock
10) Confidence 0.31 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2761850 Disease Relevance 0.36 Pain Relevance 0.05
It has been postulated that XBP-1 is important in activating the WFS1 promoter in SH-SY5Y cells [22].
Positive_regulation (important) of XBP-1 in SH-SY5Y
11) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.24 Pain Relevance 0
RT-PCR analysis revealed upregulation of the spliced form of X-box binding protein-1s, a potent transcription factor and part of the proximal ER stress sensor inositol-requiring enzyme-1 pathway.
Positive_regulation (upregulation) of X-box binding protein in proximal associated with stress
12) Confidence 0.17 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2518495 Disease Relevance 1.05 Pain Relevance 0

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