INT184720

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.23
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Smad3) intracellular (Smad3) DNA binding (Smad3)
protein complex (Smad3) cytoplasm (Smad3) nucleus (Smad3)
Anatomy Link Frequency
macrophages 1
fibroblasts 1
keratinocytes 1
neutrophils 1
Smad3 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 62 92.24 High High
antagonist 5 89.08 High High
Osteoarthritis 91 84.24 Quite High
Inflammation 126 38.40 Quite Low
cytokine 45 34.48 Quite Low
Inflammatory response 25 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Inflammatory stimuli 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 14 100.00 Very High Very High Very High
Soft Tissue Injuries 5 99.52 Very High Very High Very High
Targeted Disruption 209 96.64 Very High Very High Very High
Injury 64 94.12 High High
Pulmonary Fibrosis 40 92.24 High High
Fibrosis 47 86.84 High High
Aging 13 86.16 High High
Osteoarthritis 96 84.24 Quite High
Lung Injury 55 81.12 Quite High
Adult Respiratory Distress Syndrome 10 72.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This loss of Smad3 interfered with the chemotactic response of neutrophils, macrophages, keratinocytes, and fibroblasts to TGF?
Negative_regulation (loss) of Smad3 in macrophages
1) Confidence 0.55 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.82 Pain Relevance 0.20
Together, these data suggest that, although it is not required for binding to Smad3, the N-terminus of Sox17 is important for repression of Smad3 transcriptional activity.
Negative_regulation (repression) of Smad3 associated with repression
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.31 Pain Relevance 0
Inhibition of Smad3, or even partial reduction in its activity might afford protection against the toxicities of irradiation.
Negative_regulation (Inhibition) of Smad3
3) Confidence 0.40 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.75 Pain Relevance 0.13
Since Sox17 negatively regulated Smad3 transcriptional activity in reporter assays but did not influence Smad3 nuclear import, we sought to determine if the repression was mediated by influencing Smad3 DNA binding.
Negative_regulation (regulated) of Smad3 associated with repression
4) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.32 Pain Relevance 0
Interaction of Runx2 with Smad1 facilitates the function of Runx2 in stimulating terminal differentiation, while Smad3 blocks Runx2 function [81-83].
Negative_regulation (blocks) of Smad3
5) Confidence 0.30 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.59 Pain Relevance 0.16
This loss of Smad3 interfered with the chemotactic response of neutrophils, macrophages, keratinocytes, and fibroblasts to TGF?
Negative_regulation (loss) of Smad3 in fibroblasts
6) Confidence 0.19 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.82 Pain Relevance 0.20
This loss of Smad3 interfered with the chemotactic response of neutrophils, macrophages, keratinocytes, and fibroblasts to TGF?
Negative_regulation (loss) of Smad3 in neutrophils
7) Confidence 0.19 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.82 Pain Relevance 0.20
This loss of Smad3 interfered with the chemotactic response of neutrophils, macrophages, keratinocytes, and fibroblasts to TGF?
Negative_regulation (loss) of Smad3 in keratinocytes
8) Confidence 0.19 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1177930 Disease Relevance 0.82 Pain Relevance 0.20

General Comments

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