INT184732

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.04
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (SNCG) microtubule organizing center (SNCG) cytoplasm (SNCG)
Anatomy Link Frequency
urine 2
extracellular matrix 1
nucleus 1
SNCG (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 4 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Malignant Neoplastic Disease 12 97.60 Very High Very High Very High
Death 33 94.60 High High
Colon Cancer 158 94.32 High High
Cancer 180 93.00 High High
Recurrence 78 86.40 High High
Suicidal Behaviour 58 73.28 Quite High
Microsatellite Instability 3 70.84 Quite High
Apoptosis 18 47.76 Quite Low
Stress 8 41.52 Quite Low
Breast Cancer 40 34.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been previously reported that SNCG localizes to spindle poles [33] and translocates from perinuclear area to nucleus [34].
Localization (localizes) of SNCG in nucleus
1) Confidence 0.70 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 0.80 Pain Relevance 0
Interestingly, although SNCG gene does not have a signal peptide, suggesting it is not a secreted protein, a secreted form SNCG can be detected in serum [25,26] and urine [27] samples of malignant tumors.
Localization (secreted) of SNCG in urine associated with malignant neoplastic disease
2) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 0.75 Pain Relevance 0
Interestingly, although SNCG gene does not have a signal peptide, suggesting it is not a secreted protein, a secreted form SNCG can be detected in serum [25,26] and urine [27] samples of malignant tumors.
Neg (not) Localization (secreted) of SNCG in urine associated with malignant neoplastic disease
3) Confidence 0.61 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2912867 Disease Relevance 0.80 Pain Relevance 0
75 years leading to a dilution of the stronger decline of the total rate SR+UDR in men aged ?
Localization (decline) of SR+UDR
4) Confidence 0.27 Published 2005 Journal BMC Public Health Section Body Doc Link PMC1177964 Disease Relevance 0.44 Pain Relevance 0
AKAP6, located on the ER/SR, acts as an adapter molecule in co-localization of the PKA, which also phosphorylates and regulates the activity of KCNMA1 [44], [45].
Localization (located) of SR
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.13 Pain Relevance 0
AKAP6 is selectively expressed in brain, cardiac and skeletal muscle [36] and it is specifically localized in the SR, therefore, sequestering PKA to this organelle [36]; and (d) SGCD, a member of Sarcoglycan family critical in linking cytoskeleton to extracellular matrix.
Localization (localized) of SR in extracellular matrix
6) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935366 Disease Relevance 0.13 Pain Relevance 0

General Comments

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