INT184742

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.29
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (MAP2) cytoskeleton (MAP2) intracellular (MAP2)
cytoplasm (MAP2)
Anatomy Link Frequency
neuronal 1
dendrites 1
neurite 1
MAP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 18 67.92 Quite High
Glutamate 4 50.60 Quite High
cva 5 8.36 Low Low
Fibrositis 24 5.00 Very Low Very Low Very Low
Pain 18 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
glial activation 5 5.00 Very Low Very Low Very Low
spastic colon 5 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cerebral Amyloid Angiopathy 11 99.76 Very High Very High Very High
Syndrome 39 99.60 Very High Very High Very High
Chronic Fatigue Syndrome 262 98.68 Very High Very High Very High
Disease 22 98.56 Very High Very High Very High
Amyloidosis 9 97.40 Very High Very High Very High
Disorder Of Lipid Metabolism 5 95.76 Very High Very High Very High
Alzheimer's Dementia 14 94.36 High High
Gliosis 4 92.76 High High
Infection 19 86.20 High High
Epstein-barr Virus 2 85.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There did seem to be a slight association of MAP2 autoantibodies with duration of CFS illness.
MAP2 Binding (association) of associated with chronic fatigue syndrome
1) Confidence 0.37 Published 2005 Journal J Autoimmune Dis Section Body Doc Link PMC1177983 Disease Relevance 1.12 Pain Relevance 0.03
Phosphorylated MAP2, on the other hand, loses its cross-linking ability and destabilises the microtubule bundles, thus increasing the likelihood of a bifurcation event.
MAP2 Binding (cross) of
2) Confidence 0.36 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1679805 Disease Relevance 0 Pain Relevance 0
The elongation and branching rates are given by:

where cl is the concentration of free tubulin at a neurite tip, Bl is the concentration of dephosphorylated and microtubule-bound MAP2, Pl is the concentration of phosphorylated MAP2 and Pb, is the probability of branching.

MAP2 Binding (bound) of in neurite
3) Confidence 0.36 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1679805 Disease Relevance 0 Pain Relevance 0
Such a substance can plausibly be identified as tubulin, or possibly a microtubule-associated protein, such as MAP2, that influences the stability of microtubule bundles in dendrites.
MAP2 Binding (possibly) of in dendrites
4) Confidence 0.36 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1679805 Disease Relevance 0 Pain Relevance 0
Synaptophysin, Microtubule-Associated Protein 2 and neuronal counts
Microtubule-Associated Protein 2 Binding (counts) of in neuronal
5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866543 Disease Relevance 0.53 Pain Relevance 0.03
Apolipoproteins E, E4, and J, and microtubule-associated protein 2 have been associated with CAA syndromes and Alzheimer's disease [66,80].
microtubule-associated protein 2 Binding (associated) of associated with cerebral amyloid angiopathy, syndrome and disease
6) Confidence 0.09 Published 2005 Journal BMC Neurol Section Body Doc Link PMC1326206 Disease Relevance 1.64 Pain Relevance 0

General Comments

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