INT184751

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.35
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dck) nucleus (Dck) kinase activity (Dck)
Dck (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 6 97.44 Very High Very High Very High
palliative 3 89.40 High High
Inflammation 9 59.72 Quite High
Multiple sclerosis 129 50.00 Quite Low
Bile 1 32.24 Quite Low
imagery 24 5.00 Very Low Very Low Very Low
Central nervous system 15 5.00 Very Low Very Low Very Low
Dermatone 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Bioavailability 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 16 99.00 Very High Very High Very High
Carcinoma 17 91.68 High High
Disease 58 84.20 Quite High
Disorder Of Purine Or Pyrimidine Metabolism 3 77.56 Quite High
Lymphopenia 6 74.84 Quite High
Hepatitis 1 65.36 Quite High
Infection 20 64.92 Quite High
Inflammatory Bowel Disease 2 61.52 Quite High
Bacterial Infection 2 60.68 Quite High
INFLAMMATION 9 59.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gemcitabine is phosphorylated by deoxycytidine kinase into the active metabolite gemcitabine triphosphate (GemTP).
Phosphorylation (phosphorylated) of deoxycytidine kinase
1) Confidence 0.50 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1180427 Disease Relevance 0.90 Pain Relevance 0.12
The prodrug is resistant to degradation by adenosine desaminase and is able to enter cells via purine nucleoside transporters.52 Once within the cell, cladribine undergoes initial phosphorylation by deoxycytidine kinase (DCK) to finally become the active 2-chlorodeoxyadenosinetriposphate.53 To inactivate cladribine-triphosphate nucleotides and to prevent intracellular accumulation, dephosphorylation by 5?
Phosphorylation (dephosphorylation) of deoxycytidine kinase associated with adenocard
2) Confidence 0.21 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915536 Disease Relevance 0.15 Pain Relevance 0.09
The prodrug is resistant to degradation by adenosine desaminase and is able to enter cells via purine nucleoside transporters.52 Once within the cell, cladribine undergoes initial phosphorylation by deoxycytidine kinase (DCK) to finally become the active 2-chlorodeoxyadenosinetriposphate.53 To inactivate cladribine-triphosphate nucleotides and to prevent intracellular accumulation, dephosphorylation by 5?
Phosphorylation (phosphorylation) of deoxycytidine kinase associated with adenocard
3) Confidence 0.21 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915536 Disease Relevance 0.15 Pain Relevance 0.09
The prodrug is resistant to degradation by adenosine desaminase and is able to enter cells via purine nucleoside transporters.52 Once within the cell, cladribine undergoes initial phosphorylation by deoxycytidine kinase (DCK) to finally become the active 2-chlorodeoxyadenosinetriposphate.53 To inactivate cladribine-triphosphate nucleotides and to prevent intracellular accumulation, dephosphorylation by 5?
Phosphorylation (dephosphorylation) of DCK associated with adenocard
4) Confidence 0.21 Published 2010 Journal Drug Des Devel Ther Section Body Doc Link PMC2915536 Disease Relevance 0.15 Pain Relevance 0.09

General Comments

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