INT18476

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Context Info
Confidence 0.43
First Reported 1986
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 0.88
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CPN1) extracellular space (CPN1) extracellular region (CPN1)
Anatomy Link Frequency
CPN 2
plasma 1
urine 1
CPN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
lidocaine 2 94.72 High High
Enkephalin 6 94.16 High High
Opioid 4 83.76 Quite High
Dynorphin 2 74.88 Quite High
Angina 2 71.28 Quite High
Disease Link Frequency Relevance Heat
Myocardial Infarction 20 98.00 Very High Very High Very High
Infarction 2 92.92 High High
Angina 2 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This inhibition never increased during dorsiflexion relative to rest prior to the CPN block, but after the block a significant increase in inhibition was seen during fictive dorsiflexion in three subjects.
Negative_regulation (block) of CPN in CPN
1) Confidence 0.43 Published 1995 Journal Exp Brain Res Section Abstract Doc Link 7621944 Disease Relevance 0 Pain Relevance 0.08
When the subjects attempted to perform a dorsiflexion while the CPN was blocked ("fictive dorsi flexion"), the soleus H-reflex was strongly depressed.
Negative_regulation (blocked) of CPN in CPN
2) Confidence 0.37 Published 1995 Journal Exp Brain Res Section Abstract Doc Link 7621944 Disease Relevance 0 Pain Relevance 0.09
Urine from a patient genetically deficient in plasma carboxypeptidase N (21% of normal) contained normal levels of urinary carboxypeptidase with similar properties to that from pooled human urine.
Negative_regulation (deficient) of carboxypeptidase N in urine
3) Confidence 0.29 Published 1986 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 3812089 Disease Relevance 0 Pain Relevance 0.05
The aims of our study were to evaluate the plasma carboxypeptidase N activity in normal subjects and in patients with acute myocardial infarction and to delineate its relationship with creatine kinase-MB isoforms in monitoring of acute myocardial infarction, carboxypeptidase N being the major determinant of creatine kinase isoform conversion in plasma.
Negative_regulation (evaluate) of carboxypeptidase N in plasma associated with myocardial infarction
4) Confidence 0.10 Published 1997 Journal Eur J Clin Chem Clin Biochem Section Abstract Doc Link 9166972 Disease Relevance 0.34 Pain Relevance 0
Furthermore, high baseline levels of carboxypeptidase N will reduce the diagnosis efficiency of creatine kinase-MB isoforms in the diagnosis of acute myocardial infarction.
Negative_regulation (reduce) of carboxypeptidase N associated with myocardial infarction
5) Confidence 0.10 Published 1997 Journal Eur J Clin Chem Clin Biochem Section Abstract Doc Link 9166972 Disease Relevance 0.54 Pain Relevance 0.07
Conversely, degradation was unaffected by inhibitors of neutral endopeptidase (phosphoramidon), carboxypeptidase N (MERGETPA) or angiotensin converting enzyme (captopril).
Negative_regulation (inhibitors) of carboxypeptidase N
6) Confidence 0.10 Published 1990 Journal Biochem. Pharmacol. Section Abstract Doc Link 1974424 Disease Relevance 0 Pain Relevance 0.72

General Comments

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