INT18478

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Context Info
Confidence 0.88
First Reported 1990
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 1.75
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2) extracellular region (CSF2)
Anatomy Link Frequency
CSF 2
granulocyte 1
macrophage 1
CSF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 8 100.00 Very High Very High Very High
Pain 2 99.02 Very High Very High Very High
Neuropeptide 1 92.24 High High
Dynorphin 4 82.88 Quite High
Enkephalin 10 81.12 Quite High
headache 6 75.32 Quite High
abdominal pain 2 45.28 Quite Low
intrathecal 1 19.28 Low Low
cytokine 2 18.72 Low Low
cva 36 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 10 98.00 Very High Very High Very High
Neutrophil Disorders 22 96.80 Very High Very High Very High
Hematologic Neoplasms 1 95.88 Very High Very High Very High
Hematological Disease 2 89.24 High High
Neutropenia 3 84.24 Quite High
Agranulocytosis 17 79.56 Quite High
Pain 1 75.96 Quite High
Fever 3 75.72 Quite High
Headache 6 75.32 Quite High
Disease 41 73.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sequential administration of recombinant human interleukin-3 and granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation for malignant lymphoma: a phase I/II multicenter study.
Protein_catabolism (administration) of granulocyte-macrophage colony-stimulating factor in macrophage associated with lymphatic system cancer
1) Confidence 0.88 Published 1994 Journal Blood Section Title Doc Link 7919329 Disease Relevance 0.41 Pain Relevance 0
However, despite the potential for continuous delivery, the effects can be suboptimal because of non-selective receptor activation, and subtherapeutic concentrations because of enzymatic degradation, ependymal receptor binding and/or rapid CSF clearance.
Protein_catabolism (degradation) of CSF
2) Confidence 0.85 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2615740 Disease Relevance 0.06 Pain Relevance 0.05
[Analysis of factors for poor mobilization after administration of recombinant human granulocyte stimulating factor (rHuG-CSF) in healthy donors].
Protein_catabolism (administration) of rHuG-CSF in granulocyte associated with pain
3) Confidence 0.63 Published 2003 Journal Gan To Kagaku Ryoho Section Title Doc Link 12852351 Disease Relevance 0.32 Pain Relevance 0.25
However, less is known about their degradation in CSF.
Protein_catabolism (degradation) of CSF in CSF
4) Confidence 0.49 Published 1990 Journal Biochem. Pharmacol. Section Abstract Doc Link 1974424 Disease Relevance 0 Pain Relevance 0.37
These data are consistent with a significant role for aminopeptidase M activity in the degradation of low molecular weight opioid peptides in human CSF.
Protein_catabolism (degradation) of CSF in CSF associated with opioid
5) Confidence 0.43 Published 1990 Journal Biochem. Pharmacol. Section Abstract Doc Link 1974424 Disease Relevance 0 Pain Relevance 0.59
When G-CSF is exposed to active elastase enzyme in vitro, G-CSF is rapidly cleaved and rendered inactive [11].
Protein_catabolism (cleaved) of G-CSF
6) Confidence 0.14 Published 2004 Journal BMC Blood Disord Section Body Doc Link PMC535939 Disease Relevance 0.96 Pain Relevance 0

General Comments

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