INT184798

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.41
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PLA2G6) cytoplasm (PLA2G6)
Anatomy Link Frequency
epithelial cells 2
PLA2G6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 63 91.00 High High
Inflammation 112 50.00 Quite Low
Inflammatory mediators 24 13.32 Low Low
chemokine 17 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
bradykinin 6 5.00 Very Low Very Low Very Low
metalloproteinase 5 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 33 100.00 Very High Very High Very High
Otitis Media With Effusion 92 95.48 Very High Very High Very High
Otitis Media 134 94.16 High High
Prostate Cancer 5 90.36 High High
Colon Cancer 7 89.56 High High
Neuroblastoma 2 89.00 High High
Apoptosis 12 87.24 High High
Hyperplasia 4 83.56 Quite High
Metaplasia 4 61.36 Quite High
Glioma 1 56.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the stimulation of AA release by known cancer chemopreventative agents, I have proposed that AA release by cells is associated with cancer chemoprevention [23-27], possibly, but not necessarily, by activating a secreted tumor suppressor phospholipase A2 (PLA2) [28,29].
Positive_regulation (activating) of Localization (secreted) of PLA2 associated with cancer
1) Confidence 0.16 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC1180457 Disease Relevance 1.50 Pain Relevance 0
PLA2, exogenously administrated, increased mucous glycoprotein secretion in cultured chinchilla middle ear epithelial cells (238).
Positive_regulation (increased) of Localization (secretion) of PLA2 in epithelial cells
2) Confidence 0.08 Published 2008 Journal Clinical and Experimental Otorhinolaryngology Section Body Doc Link PMC2671742 Disease Relevance 0.91 Pain Relevance 0.05

General Comments

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