INT184825

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.14
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Thy1) endoplasmic reticulum (Thy1) plasma membrane (Thy1)
enzyme binding (Thy1) cytoskeleton organization (Thy1)
Anatomy Link Frequency
brain 2
ganglion cell 2
Thy1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 1 95.04 Very High Very High Very High
anesthesia 5 90.20 High High
agonist 1 86.56 High High
Hippocampus 45 83.56 Quite High
imagery 34 56.12 Quite High
Thalamus 23 53.60 Quite High
glial activation 4 35.36 Quite Low
Inflammation 42 32.08 Quite Low
cva 4 31.40 Quite Low
depression 5 29.40 Quite Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 133 100.00 Very High Very High Very High
Targeted Disruption 385 99.80 Very High Very High Very High
Restless Legs Syndrome 7 96.68 Very High Very High Very High
Alzheimer's Dementia 321 92.08 High High
Injury 52 91.60 High High
Down Syndrome 16 91.20 High High
Amyloid Plaque 76 90.92 High High
Congenital Anomalies 7 85.36 High High
Sprains And Strains 48 84.12 Quite High
Wallerian Degeneration 4 82.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thy1-CFP mice were genotyped to confirm the inclusion of the CFP reporter transgene under the control of the thy1 promoter.
Regulation (control) of thy1
1) Confidence 0.42 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.28 Pain Relevance 0.09
These findings underscore the value of the thy1-CFP transgenic mouse line for studies requiring the efficient identification of ganglion cells for in vivo and in vitro studies.


Regulation (value) of thy1 in ganglion cells associated with ganglion cysts and targeted disruption
2) Confidence 0.25 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.75 Pain Relevance 0.03
Higher Id2 and Lpin1 fold changes strongly correlated with higher fold changes in ganglion cell gene Thy1 (r = 0.86 and r = 0.94, respectively) and crystallin genes Cryab, Cryba4, and Crygd (0.82 > r < 0.89).
Regulation (changes) of Thy1 in ganglion cell associated with ganglion cysts
3) Confidence 0.21 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.81 Pain Relevance 0
To study axonal growth and pruning in the intact brain we used two-photon microscopy in transgenic mice expressing membrane-bound green fluorescent protein (GFP) under the thy-1 promoter [34].
Regulation (under) of thy-1 in brain associated with targeted disruption
4) Confidence 0.17 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1180514 Disease Relevance 0.18 Pain Relevance 0.07
Thy-1 mRNA is modulated by iron (Ye and Connor, 2000), and Thy-1 protein levels are markedly decreased in RLS brains.
Regulation (modulated) of Thy-1 in brains associated with restless legs syndrome
5) Confidence 0.05 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC2995617 Disease Relevance 0.84 Pain Relevance 0.09
deposits was mentioned in two lines (as briefly and incompletely described in the literature) in which hAPP, without mutation, was overexpressed under the control of a NSE [130] or a Thy-1 promoter [128].
Regulation (control) of Thy-1 promoter
6) Confidence 0.04 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 1.06 Pain Relevance 0
In a APPSLPS1M146L mouse model developed by Sanofi-Aventis, a hAPP751 gene carrying both the Swedish and the London mutations (K670N/M671L and V717I) under the control of the Thy-1 promoter is associated with a human mutant gene of presenilin-1 (PS-1 M146L) under the HMG-CoA reductase promoter (allowing a preferential cerebral expression).
Regulation (control) of Thy-1 promoter
7) Confidence 0.02 Published 2007 Journal Acta Neuropathol Section Body Doc Link PMC2100431 Disease Relevance 0.22 Pain Relevance 0

General Comments

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