INT184839

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Context Info
Confidence 0.73
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.84
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd1a) endoplasmic reticulum (Drd1a) plasma membrane (Drd1a)
nucleus (Drd1a) intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
substantia nigra 1
neurons 1
basal ganglia 1
Drd1a (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 17 98.88 Very High Very High Very High
Substantia nigra 24 98.44 Very High Very High Very High
dopamine receptor 6 97.88 Very High Very High Very High
Dopamine 282 97.60 Very High Very High Very High
adenocard 92 97.42 Very High Very High Very High
Dynorphin 8 96.24 Very High Very High Very High
projection neuron 1 95.64 Very High Very High Very High
agonist 35 83.68 Quite High
Enkephalin 4 79.60 Quite High
amygdala 6 71.76 Quite High
Disease Link Frequency Relevance Heat
Disease 11 96.76 Very High Very High Very High
Cognitive Disorder 11 94.56 High High
Sprains And Strains 7 94.16 High High
Targeted Disruption 36 87.80 High High
Parkinson's Disease 1 66.40 Quite High
Apoptosis 11 37.88 Quite Low
Hypoxia 12 29.48 Quite Low
Attention Deficit Hyperactivity Disorder 163 13.52 Low Low
Ocular Toxicity (including Many Sub-types) 11 5.00 Very Low Very Low Very Low
Death 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Photodetection of EGFP at a low voltage did not allow a correct visualization of striatal D1R neurons in drd1a-EGFP animals (Fig.
Localization (visualization) of drd1a in neurons
1) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651623 Disease Relevance 0.47 Pain Relevance 0.04
In vivo and in vitro data on adenosine-dopamine interactions were mostly obtained from investigations in the basal ganglia and limbic regions [52, 53] due to the high abundance of A1Rs, A2ARs, D1Rs, and D2Rs in these areas and their involvement in the pathology of Parkinson’s disease.
Localization (abundance) of D1R in basal ganglia associated with dopamine, adenocard and disease
2) Confidence 0.73 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.28 Pain Relevance 0.46
Messenger RNAs encoding DRD1 are selectively localized in striatal neurons projecting to the substantia nigra (direct pathway) and co-localize with dynorphin.
Localization (localized) of DRD1 in substantia nigra associated with dynorphin and substantia nigra
3) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.33
Deficient DRD1 function in SHR implies that only stimuli with strong reinforcer value will release enough DA to stimulate DRD1 sufficiently to facilitate NMDA receptor function and produce phosphorylation of CREB and other important proteins/peptides required for strengthening of synaptic connections in circuits representing goal-directed learning and memory consolidation.
Localization (release) of DRD1 associated with nmda receptor
4) Confidence 0.36 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.09 Pain Relevance 0.20

General Comments

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