INT184840

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.03
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) signal transduction (Drd2) plasma membrane (Drd2)
signal transducer activity (Drd2)
Anatomy Link Frequency
striatum 2
Drd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 153 98.08 Very High Very High Very High
Substantia nigra 7 94.92 High High
midbrain 21 94.08 High High
Serotonin 23 87.92 High High
monoamine 5 87.28 High High
antagonist 9 59.44 Quite High
Neurotransmitter 14 53.60 Quite High
agonist 9 46.52 Quite Low
addiction 1 29.92 Quite Low
Glutamate 20 27.76 Quite Low
Disease Link Frequency Relevance Heat
Schizophrenia 20 96.88 Very High Very High Very High
Cv Unclassified Under Development 1 86.60 High High
Cognitive Disorder 14 77.04 Quite High
Hypoxia 4 72.92 Quite High
Attention Deficit Hyperactivity Disorder 164 72.40 Quite High
Drug Dependence 1 30.32 Quite Low
Ocular Toxicity (including Many Sub-types) 11 5.00 Very Low Very Low Very Low
Stress 9 5.00 Very Low Very Low Very Low
Hypertension 7 5.00 Very Low Very Low Very Low
Congenital Anomalies 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, DRD1 and DRD2 mRNA levels were increased in the striatum suggesting impaired release of dopamine [185].
Positive_regulation (increased) of Transcription (levels) of DRD2 in striatum associated with dopamine
1) Confidence 0.35 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.93 Pain Relevance 0.65
The D2 receptor upregulation caused by chronic antipsychotic exposure was described in both animals (Burt et al., 1977; Ginovart et al., 2009) and patients with schizophrenia (Lee et al., 1978; Mackay et al., 1982) and now is thought to be responsible for loss of efficacy of antipsychotics.
Positive_regulation (upregulation) of Transcription (described) of D2 receptor associated with schizophrenia
2) Confidence 0.16 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0.10 Pain Relevance 0

General Comments

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