INT184841

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Context Info
Confidence 0.81
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 1.45
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
brain 2
neuronal 1
cleavage 1
synapses 1
Snap25 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 129 99.08 Very High Very High Very High
GABAergic 45 99.08 Very High Very High Very High
anesthesia 8 94.96 High High
nMDA receptor 11 92.40 High High
Neuropeptide 22 90.40 High High
Thalamus 4 90.12 High High
Spinal cord 47 87.20 High High
Hippocampus 27 86.84 High High
Glutamate 23 81.08 Quite High
gABA 2 80.52 Quite High
Disease Link Frequency Relevance Heat
Cognitive Disorder 30 97.04 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 178 96.76 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 11 95.56 Very High Very High Very High
Epilepsy 6 87.36 High High
Ataxia 4 73.28 Quite High
Convulsion 39 69.04 Quite High
Anxiety Disorder 15 58.88 Quite High
Brain Disease 2 53.76 Quite High
Ganglion Cysts 40 51.36 Quite High
Anaerobic Bacterial Infections 22 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the reason for discrepancy between these observations and our previous results demonstrating co-localization of SNAP-25 immunoreactivity with GABAergic markers in several GABAergic neuronal populations [5] remains to be resolved, our present findings indicate that SNAP-25b RNA transcripts are, in fact, robustly expressed by GABAergic neurons isolated from cortex, thalamus, caudate, as well as by hippocampal interneurons at a level comparable to that seen in excitatory, glutaminergic neurons.
Localization (localization) of SNAP-25 in neuronal associated with gabaergic and thalamus
1) Confidence 0.81 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.47
This difference in subcellular localization of the two SNAP-25 isoforms might contribute to the phenotype of the mutants.
Localization (localization) of SNAP-25
2) Confidence 0.75 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0
Thus, the absence of SNAP-25b results in progressing pathological changes in brain areas important for cognitive functions.


Localization (absence) of SNAP-25b in brain associated with cognitive disorder
3) Confidence 0.75 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.31 Pain Relevance 0.20
For quantification of total SNAP-25 mRNA; 1 µg RNA, 10 µµ of each primer and a trace of [?
Localization (quantification) of SNAP-25 mRNA
4) Confidence 0.66 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0.09
The decreased immunostaining intensity for SNAP-25 is explained by the decreased formation of the oligomerized SNARE complex and the diffuse localization of SNAP-25 on the synaptic membrane in tomosyn-deficient mice.


Localization (localization) of SNAP-25
5) Confidence 0.48 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
This distinct distribution supports the faint colocalization of SNAP-25 with tomosyn on the immunostained brain sections.
Localization (colocalization) of SNAP-25 in brain
6) Confidence 0.48 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.07
Syntaxin-1, SNAP-25, the mixture of syntaxin-1 and SNAP-25, or the mixture of syntaxin-1, SNAP-25, and VAMP-2 was incubated with MBP, MBP-tomosyn-?
Localization (mixture) of SNAP-25
7) Confidence 0.45 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0.05 Pain Relevance 0
Syntaxin-1, SNAP-25, the mixture of syntaxin-1 and SNAP-25, or the mixture of syntaxin-1, SNAP-25, and VAMP-2 was incubated with MBP, MBP-tomosyn-?
Localization (mixture) of SNAP-25
8) Confidence 0.45 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
Syntaxin-1, SNAP-25, the mixture of syntaxin-1 and SNAP-25, or the mixture of syntaxin-1, SNAP-25, and VAMP-2 was incubated with MBP, MBP-tomosyn-?
Localization (mixture) of SNAP-25
9) Confidence 0.45 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0
Since it is known that cleavage of SNAP-25 by BoNT/A influences the dynamics of quantal release at other synapses (Sakaba et al. 2005), we attempted to define these changes in more detail.
Localization (cleavage) of SNAP-25 in synapses
10) Confidence 0.34 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0 Pain Relevance 0
As BoNT/A and BoNT/E cleave SNAP-25 instead of syb II, we were able to inhibit exocytosis in neurons while still monitor the entry of TeNT through cleavage of syb II.
Localization (cleave) of SNAP-25 in cleavage
11) Confidence 0.27 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0 Pain Relevance 0.16
SNAP-25 regulates membrane trafficking and is involved in the release of all neurotransmitters as well as regulating translocation of proteins (e.g.
Localization (involved) of SNAP-25 associated with neurotransmitter
12) Confidence 0.15 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 1.09 Pain Relevance 0.10

General Comments

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