INT184843

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 2.15
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
neuronal 4
neurons 4
chromaffin cells 2
GABAergic neurons 2
cortex 2
Snap25 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 91 99.82 Very High Very High Very High
Glutamate 40 99.08 Very High Very High Very High
nMDA receptor 11 98.68 Very High Very High Very High
Thalamus 28 98.60 Very High Very High Very High
Dopamine 154 98.56 Very High Very High Very High
GABAergic 316 97.92 Very High Very High Very High
Hippocampus 46 96.36 Very High Very High Very High
Neuropeptide 14 79.36 Quite High
Pyramidal cell 65 76.00 Quite High
gABA 7 55.28 Quite High
Disease Link Frequency Relevance Heat
Cognitive Disorder 19 95.28 Very High Very High Very High
Targeted Disruption 38 93.52 High High
Ocular Toxicity (including Many Sub-types) 11 92.48 High High
Psychosis 4 91.00 High High
Attention Deficit Hyperactivity Disorder 168 90.08 High High
Schizophrenia 21 85.16 High High
Brain Disease 2 67.36 Quite High
Ataxia 2 65.48 Quite High
Disease 2 47.36 Quite Low
Epilepsy 2 26.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in the preceding experiments we did not detect a significant effect of SNAP-25 expression on the modulation of calcium responses in cultured neurons.
Regulation (effect) of Gene_expression (expression) of SNAP-25 in neurons
1) Confidence 0.62 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.12
Since the relative expression of the SNAP-25 isoforms is dynamically regulated in cortex and other brain regions during development [15,16], we next investigated the relative abundance of the specific transcripts in GFPpos and GFPneg populations of cortical neurons prepared from P7 mice.
Regulation (regulated) of Gene_expression (expression) of SNAP-25 in cortex
2) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.17
To examine the level of SNAP-25 mRNA expression in the selected cell populations, we further compared the qRT-PCR amplification of SNAP-25 isoform transcripts to ?
Spec (examine) Regulation (level) of Gene_expression (expression) of SNAP-25 mRNA
3) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.23
Furthermore, the expression of the variant SNAP-25 isoforms has been shown to affect the size of the RRP in hippocampal neurons [11], as well as in adrenal chromaffin cells [4,31], and has been suggested to contribute to developmental changes in hippocampal short-term synaptic plasticity [22].
Regulation (affect) of Gene_expression (expression) of SNAP-25 in chromaffin cells
4) Confidence 0.45 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0.06 Pain Relevance 0.16
Alterations of calcium dynamics in SNAP-25 deficient neuronal cultures
Regulation (Alterations) of Gene_expression (cultures) of SNAP-25 in neuronal
5) Confidence 0.39 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.36
Knockdown of dysbindin in cultured cells affects SNAP25 expression and the extracellular glutamate or dopamine levels (Numakawa et al., 2004; Kumamoto et al., 2006).
Regulation (affects) of Gene_expression (expression) of SNAP25 associated with dopamine and glutamate
6) Confidence 0.32 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2396815 Disease Relevance 0.54 Pain Relevance 0.27
Our present findings in the SNAP-25b deficient mouse mutants suggest that even small alterations in the strictly regulated temporal and anatomical expression of SNAP-25 isoforms could add to these variations.


Regulation (alterations) of Gene_expression (expression) of SNAP-25
7) Confidence 0.27 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.43 Pain Relevance 0
Nevertheless, whether such fine-tuning due to regulation of the expression of SNAP-25 and its isoforms plays such a role in sculpting properties of synaptic transmission in specific neuronal cell-types, and in particular excitatory glutamatergic or inhibitory GABAergic neurons, has not been fully resolved [5,8,23].
Regulation (regulation) of Gene_expression (expression) of SNAP-25 in GABAergic neurons associated with gabaergic
8) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.07
One explanation for the discrepancy between our present results and the previous findings is that we selected neuronal populations primarily involved in fast, point-to-point neurotransmission, thus largely excluding neurons that primarily secrete other neurotransmitters and may depend more heavily on SNAP-25a expression [30].
Spec (may) Regulation (depend) of Gene_expression (expression) of SNAP-25a in neurons associated with neurotransmitter
9) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.16
Altered expression of SNAP-25 will therefore have diffuse effects on neuronal function.
Regulation (Altered) of Gene_expression (expression) of SNAP-25 in neuronal
10) Confidence 0.05 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 1.12 Pain Relevance 0.18

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