INT184845

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 3.25
Pain Relevance 7.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
striatum 4
Slc6a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 867 100.00 Very High Very High Very High
cocaine 1221 99.84 Very High Very High Very High
Eae 238 98.80 Very High Very High Very High
antagonist 13 89.72 High High
Serotonin 36 82.48 Quite High
monoamine 45 60.56 Quite High
Nucleus accumbens 53 56.56 Quite High
agonist 26 52.24 Quite High
fluoxetine 23 51.20 Quite High
Inflammation 84 50.00 Quite Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 6 99.84 Very High Very High Very High
Parkinson's Disease 249 99.82 Very High Very High Very High
Targeted Disruption 60 98.78 Very High Very High Very High
Syndrome 1 97.32 Very High Very High Very High
Anxiety Disorder 3 96.36 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 207 92.08 High High
Aging 36 69.28 Quite High
Sprains And Strains 49 60.84 Quite High
INFLAMMATION 104 50.00 Quite Low
Aggression 11 24.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fact that cocaine retains these effects in both heterozygous DAT-KO mice and DAT-KD mice indicates that the reduction of DAT expression and thus DAT activity to 50% and 10% of wild type mice does not by itself lead to adaptive changes that abolish the stimulating effect of cocaine and in fact, 10% DAT activity seems to be sufficient for the preservation of many normal functions, such as some cocaine responses.
Spec (seems) Negative_regulation (reduction) of Gene_expression (expression) of DAT associated with cocaine
1) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.66
Although the elevated basal DA tone is due to reduced DAT activity in all mouse lines, the causes of the reduction are different; reduced expression of wild type DAT, in heterozygous DAT-KO and DAT-KD mice, versus normal expression of a mutant DAT with lower uptake activity in DAT-CI mice.
Negative_regulation (reduced) of Gene_expression (expression) of DAT associated with dopamine
2) Confidence 0.59 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.52
A DAT knock-down mouse line (DAT-KD) has been generated which has a 90% reduction in DAT expression compared to the wild type mice [18].
Negative_regulation (reduction) of Gene_expression (expression) of DAT associated with targeted disruption
3) Confidence 0.51 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.35 Pain Relevance 0.62
Our results revealed the effects of reduced DAT expression on cocaine-elicited animal behaviors.


Negative_regulation (reduced) of Gene_expression (expression) of DAT associated with cocaine
4) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.19 Pain Relevance 0.55
DAT-KD mice provide a good animal model to test how reduced DAT expression affects cocaine-induced animal behaviors.
Negative_regulation (reduced) of Gene_expression (expression) of DAT associated with cocaine
5) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.22 Pain Relevance 0.53
Despite a dramatic reduction of DAT expression and marked elevation in basal dopamine tone, cocaine produced reward, as measured by conditioned place preference, and stimulated locomotor activity in these mice.


Negative_regulation (reduction) of Gene_expression (expression) of DAT associated with dopamine, eae and cocaine
6) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC1914080 Disease Relevance 0.07 Pain Relevance 0.73
Cocaine reward and locomotion stimulation in mice with reduced dopamine transporter expression

Background

Negative_regulation (reduced) of Gene_expression (expression) of dopamine transporter associated with dopamine and cocaine
7) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Title Doc Link PMC1914080 Disease Relevance 0.08 Pain Relevance 0.59
Although the elevated basal DA tone is due to reduced DAT activity in all mouse lines, the causes of the reduction are different; reduced expression of wild type DAT, in heterozygous DAT-KO and DAT-KD mice, versus normal expression of a mutant DAT with lower uptake activity in DAT-CI mice.
Negative_regulation (reduced) of Gene_expression (expression) of DAT-KO associated with dopamine
8) Confidence 0.43 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0 Pain Relevance 0.52
Importantly, in the frontal cortex, where DAT levels are normally low in comparison to the striatum, tissue DA concentration is also low and can be more significantly affected than in the striatum by ?
Negative_regulation (low) of Gene_expression (levels) of DAT in striatum associated with dopamine and urological neuroanatomy
9) Confidence 0.39 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.10 Pain Relevance 0.80
This promoter modification results in a 90% reduction in DAT expression [18].
Negative_regulation (reduction) of Gene_expression (expression) of DAT
10) Confidence 0.38 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1914080 Disease Relevance 0.06 Pain Relevance 0.26
We examined the cocaine induced behavior of DAT knockdown mice that have DAT expression reduced by 90% when compared to the wild type mice.
Negative_regulation (reduced) of Gene_expression (expression) of DAT associated with cocaine
11) Confidence 0.38 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC1914080 Disease Relevance 0.08 Pain Relevance 0.70
A reduction in DAT expression and elevation of dopaminergic tone do not lead to adaptive changes that abolish the rewarding and stimulating effects of cocaine.
Negative_regulation (reduction) of Gene_expression (expression) of DAT associated with cocaine
12) Confidence 0.38 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC1914080 Disease Relevance 0.07 Pain Relevance 0.70
Accordingly, we examined TH and DAT striatal expression using RT-PCR, immunohistochemistry coupled to confocal microscopy, and western blot (WB) analyses.
Spec (examined) Negative_regulation (examined) of Spec (examined) Gene_expression (expression) of DAT
13) Confidence 0.25 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.61 Pain Relevance 0.14
HCT1026 inhibits MPTP-induced loss of striatal TH and DAT at mRNA and protein levels
Negative_regulation (loss) of Gene_expression (protein) of DAT associated with parkinson's disease
14) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.70 Pain Relevance 0.16
DAT knockdown, achieved by reducing DAT promotor strength, reduces adult DAT expression to 10% of wild-type levels and raises extracellular dopamine levels in the striatum to 170% of wild-type controls [175].
Negative_regulation (reduces) of Gene_expression (expression) of DAT in striatum associated with dopamine
15) Confidence 0.06 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.72 Pain Relevance 0.33

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