INT184846

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Context Info
Confidence 0.19
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.28
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd5) plasma membrane (Drd5) signal transducer activity (Drd5)
Drd5 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 608 100.00 Very High Very High Very High
monoamine 20 99.08 Very High Very High Very High
Serotonin 88 94.88 High High
Neurotransmitter 32 58.20 Quite High
Hippocampus 16 26.88 Quite Low
imagery 8 5.68 Low Low
midbrain 84 5.00 Very Low Very Low Very Low
Glutamate 80 5.00 Very Low Very Low Very Low
Nucleus accumbens 72 5.00 Very Low Very Low Very Low
Locus ceruleus 52 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 652 99.68 Very High Very High Very High
Mental Disorders 4 70.24 Quite High
Cognitive Disorder 36 66.32 Quite High
Brain Disease 8 22.80 Low Low
Stress 20 12.88 Low Low
Hypertension 28 11.96 Low Low
Ocular Toxicity (including Many Sub-types) 44 5.00 Very Low Very Low Very Low
Hypoxia 16 5.00 Very Low Very Low Very Low
Sprains And Strains 12 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Alternatively, altered calcyon function could impair DRD1/DRD5 function by affecting the switch from Gs to Gq coupling, thereby also altering intracellular calcium concentration.
Negative_regulation (impair) of DRD5
1) Confidence 0.19 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.29 Pain Relevance 0.11
Increased intracellular calcium could interfere with calcyon translocation to the cell membrane and thereby impair DRD1/DRD5 function.
Negative_regulation (impair) of DRD5
2) Confidence 0.19 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.28 Pain Relevance 0.11
These include the dopamine D1, D4 and D5 receptor (DRD1, DRD4, DRD5) genes, the ?
Negative_regulation (include) of DRD5 associated with dopamine
3) Confidence 0.18 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.86 Pain Relevance 0.23
These include the dopamine D1, D4 and D5 receptor (DRD1, DRD4, DRD5) genes, the ?
Negative_regulation (include) of D5 receptor associated with dopamine
4) Confidence 0.18 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.85 Pain Relevance 0.23

General Comments

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