INT184852

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Context Info
Confidence 0.40
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 5.06
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
impression 2
striatum 2
upper end 2
ADHD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 13 98.80 Very High Very High Very High
Dopamine 448 97.88 Very High Very High Very High
monoamine 13 97.28 Very High Very High Very High
Central nervous system 7 83.12 Quite High
addiction 18 82.36 Quite High
Neurotransmitter 56 81.52 Quite High
drug abuse 29 80.40 Quite High
Substantia nigra 15 80.28 Quite High
midbrain 42 79.44 Quite High
depression 24 73.44 Quite High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 1162 100.00 Very High Very High Very High
Cognitive Disorder 36 98.76 Very High Very High Very High
Syndrome 39 93.56 High High
Urological Neuroanatomy 4 89.24 High High
Congenital Anomalies 11 88.12 High High
Substance Abuse 65 82.36 Quite High
Alcohol Addiction 13 81.60 Quite High
Psychosis 10 80.88 Quite High
Hypertension 20 80.20 Quite High
Thyroid Disease 2 79.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ADHD and many other complex disorders represent the upper end of a continuum of severity
Positive_regulation (upper end) of Gene_expression (represent) of ADHD in upper end associated with attention deficit hyperactivity disorder
1) Confidence 0.40 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1352384 Disease Relevance 1.49 Pain Relevance 0.12
In 10 patients treated with MPH, single photon emission computed tomography (SPECT) imaging demonstrated that MPH lowered striatal DAT availability in adults with ADHD.52
Positive_regulation (with) of Gene_expression (adults) of ADHD associated with attention deficit hyperactivity disorder and imagery
2) Confidence 0.40 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732009 Disease Relevance 0.49 Pain Relevance 0.30
Further, approximately 11% of students without ADHD reported using MPH or amphetamine for recreational purposes.70
Positive_regulation (using) of Gene_expression (reported) of ADHD associated with attention deficit hyperactivity disorder
3) Confidence 0.40 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732009 Disease Relevance 0.91 Pain Relevance 0.10
While this polymorphic gene may play a significant role in ADHD predisposition, it must be tied to a certain subset of additional genes for the clinical expression of ADHD.
Positive_regulation (role) of Gene_expression (predisposition) of ADHD associated with attention deficit hyperactivity disorder
4) Confidence 0.20 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.43 Pain Relevance 0.34
The rate of improvement according to the psychiatrist rated clinical global impression (CGI-I) for ADHD was statistically significantly higher for both IR-MPH (tid) (?
Positive_regulation (for) of Gene_expression (higher) of ADHD in impression associated with attention deficit hyperactivity disorder
5) Confidence 0.20 Published 2007 Journal BMC Psychiatry Section Body Doc Link PMC2075491 Disease Relevance 0.10 Pain Relevance 0
Although not every study found increased DAT [36,37], there is a strong possibility that the DAT1 gene is overexpressed in the striatum of ADHD subjects, and that this results in reduced synaptic dopamine.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of ADHD in striatum associated with dopamine and attention deficit hyperactivity disorder
6) Confidence 0.06 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.92 Pain Relevance 0.20
Insight provided by animal models of ADHD
Positive_regulation (models) of Gene_expression (models) of ADHD associated with attention deficit hyperactivity disorder
7) Confidence 0.06 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.72 Pain Relevance 0.60

General Comments

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