INT184857

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Context Info
Confidence 0.23
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.59
Pain Relevance 2.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Lmo1) nucleus (Lmo1)
Anatomy Link Frequency
striatum 1
cortex 1
Lmo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 747 98.80 Very High Very High Very High
Nucleus accumbens 78 88.48 High High
depression 18 75.12 Quite High
long-term potentiation 3 66.56 Quite High
imagery 24 64.96 Quite High
Glutamate 63 38.64 Quite Low
nMDA receptor 33 36.64 Quite Low
midbrain 63 23.80 Low Low
Substantia nigra 24 23.60 Low Low
Serotonin 129 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 1401 99.84 Very High Very High Very High
Stress 36 90.72 High High
Targeted Disruption 21 87.36 High High
Affective Disorder 6 75.68 Quite High
Depression 21 75.12 Quite High
Conduct Disorder 69 74.48 Quite High
Attention Deficit And Disruptive Behavior Disorders 39 74.32 Quite High
Tourette's Syndrome 51 69.56 Quite High
Urological Neuroanatomy 6 24.96 Low Low
Syndrome 90 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A likely explanation could also be that elevated extracellular dopamine levels could have resulted from decreased DAT1 expression during the first postnatal month of SHR [50] which caused compensatory upregulation of both DAT1 and DRD2 receptors [51,58,77].
Positive_regulation (upregulation) of DAT1 associated with dopamine
1) Confidence 0.23 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.15 Pain Relevance 0.61
Increased d-amphetamine stimulated, DAT-mediated, release of dopamine from SHR prefrontal cortex and striatum is consistent with upregulation of DAT1 in adult SHR [58].
Positive_regulation (upregulation) of DAT1 in cortex associated with dopamine
2) Confidence 0.23 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.22 Pain Relevance 0.57
While the presence of hyperactivity in the absence of DAT1 genes may seem to conflict with the above results, suggesting hyperactivity in the presence of increased activity of the human DAT1 gene, the presence of compensatory and plastic changes in other dopaminergic systems occurring when major defects of the dopamine transporter are present from conception, may account for the differences.
Positive_regulation (increased) of DAT1 gene associated with dopamine and attention deficit hyperactivity disorder
3) Confidence 0.16 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 1.03 Pain Relevance 0.16
In contrast to the above results, LaHoste et al (1996) did not find a significant increase in the frequency of the DAT1 10 allele in their group of ADHD subjects.
Positive_regulation (increase) of DAT1 associated with attention deficit hyperactivity disorder
4) Confidence 0.11 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 1.23 Pain Relevance 0.08
Of the 10 studied, eight were positive for a role of the DAT1 gene in ADHD.
Positive_regulation (role) of DAT1 gene associated with attention deficit hyperactivity disorder
5) Confidence 0.11 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 1.73 Pain Relevance 0.04
Increased d-amphetamine stimulated, DAT-mediated, release of dopamine from SHR prefrontal cortex and striatum is consistent with upregulation of DAT1 in adult SHR [58].
Positive_regulation (upregulation) of DAT1 in striatum associated with dopamine
6) Confidence 0.08 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.22 Pain Relevance 0.57

General Comments

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