INT184864

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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 8.09
Pain Relevance 8.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Lmo1) nucleus (Lmo1)
Anatomy Link Frequency
shell 2
caudate nucleus 1
striatum 1
amygdala 1
midbrain 1
Lmo1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 2243 100.00 Very High Very High Very High
Catechol-O-methyltransferase 32 99.72 Very High Very High Very High
Nucleus accumbens 260 99.46 Very High Very High Very High
midbrain 294 98.76 Very High Very High Very High
Neurotransmitter 157 98.04 Very High Very High Very High
Glutamate 284 95.96 Very High Very High Very High
Hippocampus 61 94.04 High High
amygdala 58 93.40 High High
antagonist 132 93.24 High High
dopamine receptor 15 92.40 High High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 2586 100.00 Very High Very High Very High
Anxiety Disorder 678 99.92 Very High Very High Very High
Congenital Anomalies 38 99.92 Very High Very High Very High
Stress 77 94.20 High High
Hypertension 98 92.56 High High
Urological Neuroanatomy 28 91.64 High High
Syndrome 46 82.96 Quite High
Sprains And Strains 43 78.68 Quite High
Depression 26 72.08 Quite High
Cognitive Disorder 128 56.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, consistent with increased DAT1 expression in adult SHR striatum, extracellular dopamine levels are decreased in the caudate nucleus [55,56] and d-amphetamine-stimulated release of dopamine via DAT1 is greater in SHR striatum than WKY [54,57,58].
Gene_expression (expression) of DAT1 in caudate nucleus associated with dopamine
1) Confidence 0.26 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.15 Pain Relevance 0.67
In adults, increased expression of DAT1 might be expected to increase reuptake of dopamine, thereby reducing the need for synthesis by DOPA decarboxylase.
Gene_expression (expression) of DAT1 associated with dopamine
2) Confidence 0.26 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.23 Pain Relevance 0.61
A possible disturbance in the regulation of the DAT1 gene is in agreement with findings that DAT1 gene expression is transiently reduced in SHR midbrain during the first postnatal month and increased in adult SHR compared to controls [50,51].
Gene_expression (expression) of DAT1 gene in midbrain associated with midbrain
3) Confidence 0.26 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.55 Pain Relevance 0.27
Decreased expression of DAT1 will reduce reuptake and increase metabolism of dopamine.
Gene_expression (expression) of DAT1 associated with dopamine
4) Confidence 0.26 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.48 Pain Relevance 0.39
Although not every study found increased DAT [36,37], there is a strong possibility that the DAT1 gene is overexpressed in the striatum of ADHD subjects, and that this results in reduced synaptic dopamine.
Gene_expression (overexpressed) of DAT1 gene in striatum associated with dopamine and attention deficit hyperactivity disorder
5) Confidence 0.26 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.91 Pain Relevance 0.20
Alterations in DAT1 gene expression can affect dopamine uptake and reutilization.
Gene_expression (expression) of DAT1 gene associated with dopamine
6) Confidence 0.26 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.49 Pain Relevance 0.35
A likely explanation could also be that elevated extracellular dopamine levels could have resulted from decreased DAT1 expression during the first postnatal month of SHR [50] which caused compensatory upregulation of both DAT1 and DRD2 receptors [51,58,77].
Gene_expression (expression) of DAT1 associated with dopamine
7) Confidence 0.26 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.15 Pain Relevance 0.61
These findings suggest that increased expression of the DAT1 gene may reflect an attempt to compensate for increased tonic extracellular dopamine in the nucleus accumbens shell of SHR or increased DAT1 expression may occur in an attempt to compensate for decreased function of DAT1 in adult SHR striatum.
Gene_expression (expression) of DAT1 in shell associated with nucleus accumbens and dopamine
8) Confidence 0.26 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.57 Pain Relevance 0.49
Reduced DAT1 expression at a young age would reduce dopamine reuptake, thereby reducing dopamine reutilization and necessitating increased synthesis of dopamine by DOPA decarboxylase.
Gene_expression (expression) of DAT1 associated with dopamine
9) Confidence 0.26 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.30 Pain Relevance 0.60
These findings suggest that increased expression of the DAT1 gene may reflect an attempt to compensate for increased tonic extracellular dopamine in the nucleus accumbens shell of SHR or increased DAT1 expression may occur in an attempt to compensate for decreased function of DAT1 in adult SHR striatum.
Gene_expression (expression) of DAT1 gene in shell associated with nucleus accumbens and dopamine
10) Confidence 0.26 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.41 Pain Relevance 0.57
Differences in dopamine metabolism have been reported for children and adults with ADHD [52,53] which is consistent with developmental changes in DAT1 expression and consequent changes in dopamine uptake.
Gene_expression (expression) of DAT1 associated with dopamine and attention deficit hyperactivity disorder
11) Confidence 0.26 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.42 Pain Relevance 0.50
These findings are consistent with increased expression of DAT1 increasing dopamine re-uptake and reutilization thereby reducing metabolism.
Gene_expression (expression) of DAT1 associated with dopamine
12) Confidence 0.20 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.17 Pain Relevance 0.81
This deficiency could result from increased expression of DAT1, impaired dopamine synthesis, impaired release, or impaired regulation of extracellular dopamine by glutamate afferents from the prefrontal cortex, hippocampus, or amygdala [102].
Gene_expression (expression) of DAT1 in amygdala associated with glutamate, dopamine, hippocampus and amygdala
13) Confidence 0.20 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.16 Pain Relevance 0.97
The reduced reactivity to psychostimulants may be associated with abnormalities in DAT1 gene expression [50,51] [Mill et al., unpublished] and dopamine hypofunction as a result of adaptation to increased availability of dopamine at an early stage of development with subsequent reorganization of neural mechanisms that control VTA dopamine neuron function [139].
Gene_expression (expression) of DAT1 gene in neural associated with dopamine, congenital anomalies and midbrain
14) Confidence 0.20 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.43 Pain Relevance 0.37
In this regard, the extant evidence tends to support the novel concept of an adjunctive polypharmacy approach for the prevention and treatment of ADHD rather than single neurochemical and/or neurogenetic targets (eg, D1-D5, DAT1, DBH, COMT, 5HT1B, NR4A2, SLC1A3, BDNF, as well as loci at 4q13.2, 5q33.3, 11q22 and 17p11 [see above]).
Neg (prevention) Gene_expression (prevention) of DAT1 associated with catechol-o-methyltransferase and attention deficit hyperactivity disorder
15) Confidence 0.15 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.58 Pain Relevance 0.05
In Korea, we investigated the differences of genotype distributions of the DAT1 gene between 115 OCD patients and 160 normal controls.70 Because a previous study showed that the 10-repeats allele is reported to increase DAT1 gene expression compared with the 7-, 9-, and 11-repeats alleles,71 we classified the genotype of DAT1 into 10/10-repeats and non-10/10-repeats groups.
Gene_expression (expression) of DAT1 gene associated with anxiety disorder
16) Confidence 0.13 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.69 Pain Relevance 0.19
Dopamine transporter gene (DAT1)
Gene_expression (Dopamine transporter gene) of DAT1 associated with dopamine
17) Confidence 0.11 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.76 Pain Relevance 0.57
Frisch et al.38 reported that there was no association between the DAT1 gene and OCD in Jews, and Hemmings et al.28 also did not find any difference in the distribution of DAT1 VNTR between the OCD and control groups.
Gene_expression (distribution) of DAT1 associated with anxiety disorder
18) Confidence 0.11 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687723 Disease Relevance 0.64 Pain Relevance 0.26

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