INT184878

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Context Info
Confidence 0.04
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.33
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Lmo1) nucleus (Lmo1)
Lmo1 (Rattus norvegicus)
ADHD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 18 94.16 High High
Catechol-O-methyltransferase 10 92.64 High High
Dopamine 346 91.24 High High
midbrain 21 85.04 High High
Neurotransmitter 68 80.00 Quite High
GABAergic 4 69.28 Quite High
Neurobehavioral 2 51.76 Quite High
Biofeedback 6 50.96 Quite High
Nucleus accumbens 34 46.04 Quite Low
Glutamate 22 44.40 Quite Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 771 100.00 Very High Very High Very High
Sprains And Strains 5 90.00 High High
Syndrome 59 79.60 Quite High
Stuttering 2 66.24 Quite High
Anxiety Disorder 21 65.28 Quite High
Tics 22 62.32 Quite High
Conduct Disorder 46 61.84 Quite High
Hypertension 7 40.16 Quite Low
Cognitive Disorder 13 28.00 Quite Low
Stress 19 18.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In terms of polygenic inheritance, Hawi et al (2005) observed that several genes are associated with ADHD, including DAT1, DBH, DRD4, DRD5 and 5HT1B.
DAT1 Binding (associated) of ADHD associated with attention deficit hyperactivity disorder
1) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 0.47 Pain Relevance 0.23
They found that three dopaminergic genes, DRD2, DAT1, and DBH, differentially associated with ADHD probands.
DAT1 Binding (associated) of ADHD associated with attention deficit hyperactivity disorder
2) Confidence 0.04 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 1.14 Pain Relevance 0.11
No differences were found in DRD2 or DRD4 genes but a 160 bp insertion was found in the non-coding region upstream of exon 3 of the DAT1 gene which is of significance since variable number tandem repeats in the 3'-untranslated region of the DAT gene has been associated with ADHD in several family studies [7,9,10,14,15].
DAT1 gene Binding (associated) of ADHD associated with attention deficit hyperactivity disorder
3) Confidence 0.02 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.72 Pain Relevance 0.19

General Comments

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