INT18489

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Context Info
Confidence 0.48
First Reported 1982
Last Reported 2005
Negated 1
Speculated 3
Reported most in Abstract
Documents 59
Total Number 62
Disease Relevance 11.27
Pain Relevance 29.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

carbohydrate metabolic process (Man2a2)
Anatomy Link Frequency
hypothalamus 6
hippocampus 5
cortex 5
nerve 4
brain 3
Man2a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 65 100.00 Very High Very High Very High
Dopamine 36 100.00 Very High Very High Very High
Opioid 12 100.00 Very High Very High Very High
tolerance 11 100.00 Very High Very High Very High
Serotonin 10 100.00 Very High Very High Very High
opiate 8 100.00 Very High Very High Very High
Pain 7 100.00 Very High Very High Very High
monoamine 5 100.00 Very High Very High Very High
Clonidine 86 99.98 Very High Very High Very High
Potency 12 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 6 100.00 Very High Very High Very High
Shock 32 99.92 Very High Very High Very High
Anxiety Disorder 15 99.66 Very High Very High Very High
Syndrome 6 99.60 Very High Very High Very High
Hypotension 12 99.54 Very High Very High Very High
Stress 16 99.28 Very High Very High Very High
Experimental Arthritis 1 98.72 Very High Very High Very High
Urological Neuroanatomy 7 98.40 Very High Very High Very High
Pressure And Volume Under Development 1 97.60 Very High Very High Very High
Nervous System Injury 4 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, there was no change in alpha 2-adrenoceptor binding in the cortex, while increased binding was found in the hypothalamus.
alpha 2 Binding (binding) of in hypothalamus
1) Confidence 0.48 Published 1983 Journal Neuroscience Section Abstract Doc Link 6300728 Disease Relevance 0 Pain Relevance 0.18
The effects of ten once-daily injections of desmethylimipramine (10 mg/kg i.p.) on alpha 2- and beta-adrenoceptor binding were investigated in the rat cortex, hippocampus and hypothalamus. [3H]clonidine and [3H]dihydroalprenolol were used as ligands for alpha 2- and beta-adrenoceptors, respectively.
alpha 2 Binding (binding) of in hypothalamus associated with hippocampus and clonidine
2) Confidence 0.48 Published 1983 Journal Neuroscience Section Abstract Doc Link 6300728 Disease Relevance 0 Pain Relevance 0.18
The intrathecal administration of clonidine to rats results in profound antinociception which is thought to be mediated through an interaction of the agonist with spinal alpha-2 adrenergic receptors.
alpha-2 Binding (interaction) of in spinal associated with antinociception, agonist, clonidine and intrathecal
3) Confidence 0.47 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7791075 Disease Relevance 0 Pain Relevance 0.89
One day after the last morphine pellet implantation, alpha 2 adrenoceptor binding was assessed in vitro in the locus coeruleus (LC) and the spinal cord (SC).
alpha 2 Binding (binding) of in spinal cord associated with locus ceruleus, spinal cord and morphine
4) Confidence 0.43 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780290 Disease Relevance 0.07 Pain Relevance 1.82
These observations suggest a potent synergistic interaction between spinal mu and alpha 2 adrenergic receptor systems.
alpha 2 Binding (interaction) of in spinal
5) Confidence 0.42 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1974633 Disease Relevance 0 Pain Relevance 0.99
We conclude that the anxiolytic-like actions of alpha-2 agonists are not due to binding to alpha-2 receptors on the stress-sensitive mesoprefrontal dopamine neurons.
alpha-2 Binding (binding) of in dopamine neurons associated with stress, dopamine, anxiety disorder and agonist
6) Confidence 0.37 Published 2004 Journal Brain Res. Section Abstract Doc Link 15494168 Disease Relevance 0.75 Pain Relevance 0.60
We conclude that the anxiolytic-like actions of alpha-2 agonists are not due to binding to alpha-2 receptors on the stress-sensitive mesoprefrontal dopamine neurons.
alpha-2 Binding (binding) of in dopamine neurons associated with stress, dopamine, anxiety disorder and agonist
7) Confidence 0.37 Published 2004 Journal Brain Res. Section Abstract Doc Link 15494168 Disease Relevance 0.74 Pain Relevance 0.55
BACKGROUND: Data on the analgesic properties of alpha 2 agonists and their interactions with opioids are conflicting.
alpha 2 Binding (interactions) of associated with analgesic, agonist and opioid
8) Confidence 0.37 Published 1994 Journal Anesthesiology Section Abstract Doc Link 7916547 Disease Relevance 0 Pain Relevance 0.66
The effects of ten once-daily injections of desmethylimipramine (10 mg/kg i.p.) on alpha 2- and beta-adrenoceptor binding were investigated in the rat cortex, hippocampus and hypothalamus. [3H]clonidine and [3H]dihydroalprenolol were used as ligands for alpha 2- and beta-adrenoceptors, respectively.
alpha 2 Binding (ligands) of in cortex associated with hippocampus and clonidine
9) Confidence 0.37 Published 1983 Journal Neuroscience Section Abstract Doc Link 6300728 Disease Relevance 0 Pain Relevance 0.18
In both the rat and human thoracic spinal cord, high densities of alpha 2 binding sites were associated with the substantia gelatinosa and the intermediolateral cell column.
alpha 2 Binding (associated) of in substantia gelatinosa associated with substantia gelatinosa, urological neuroanatomy and spinal cord
10) Confidence 0.36 Published 1984 Journal Brain Res. Section Abstract Doc Link 6324960 Disease Relevance 0.10 Pain Relevance 0.47
The effects of ten, once-daily electroconvulsive shocks on alpha 2 and beta-adrenoceptor binding were investigated in the rat cortex, hippocampus, hypothalamus and cerebellum. [3H]Clonidine and [3H]dihydroalprenolol were used as radioligands for alpha 2 and beta-adrenoceptors respectively.
alpha 2 Binding (radioligands) of in hippocampus associated with shock, hippocampus and clonidine
11) Confidence 0.35 Published 1982 Journal Neuroscience Section Abstract Doc Link 6289181 Disease Relevance 0.27 Pain Relevance 0.23
The effects of ten, once-daily electroconvulsive shocks on alpha 2 and beta-adrenoceptor binding were investigated in the rat cortex, hippocampus, hypothalamus and cerebellum. [3H]Clonidine and [3H]dihydroalprenolol were used as radioligands for alpha 2 and beta-adrenoceptors respectively.
alpha 2 Binding (binding) of in hypothalamus associated with shock, hippocampus and clonidine
12) Confidence 0.33 Published 1982 Journal Neuroscience Section Abstract Doc Link 6289181 Disease Relevance 0.26 Pain Relevance 0.21
The interaction between the alpha 2 agonists and the opioids remained present when a more profound criterion of analgesia (tail-withdrawal reaction latency > or = 30 s) was used.
alpha 2 Binding (interaction) of in tail
13) Confidence 0.32 Published 1994 Journal Anesthesiology Section Body Doc Link 7916547 Disease Relevance 0 Pain Relevance 0
Using a fixed-dose analysis and an isobolographic paradigm, the spinal interaction between the alpha 2-adrenoceptor agonist clonidine and the N-methyl-D-aspartate antagonist MK-801 is characterized in a rat model of nerve injury-induced tactile hyperesthesia.
alpha 2 Binding (interaction) of in nerve associated with hyperesthesia, nervous system injury, antagonist, hyperaesthesia, agonist and clonidine
14) Confidence 0.32 Published 1995 Journal Anesthesiology Section Abstract Doc Link 7879942 Disease Relevance 0.55 Pain Relevance 0.76
In an attempt to evaluate the possible functional role of alpha-2 adrenoceptors located on noradrenergic nerve endings in the regulation of cerebral norepinephrine metabolism, we have measured the effects of clonidine and idazoxan on cerebral free 3,4-dihydroxyphenylethyleneglycol (DOPEG) levels (an index of norepinephrine turnover) in the rat after surgical and experimental manipulations that allow an exclusive interaction of the alpha-2 adrenergic agents with presynaptic alpha-2 autoreceptors.
alpha-2 Binding (interaction) of in nerve associated with clonidine
15) Confidence 0.31 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3027307 Disease Relevance 0 Pain Relevance 0.22
Combinations of alpha 2 agonists and opiates are used in the clinical management of pain to harness their potential synergistic interaction for analgesia while limiting their side-effects.
alpha 2 Binding (interaction) of associated with pain, agonist, opiate and analgesia
16) Confidence 0.29 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780290 Disease Relevance 0.10 Pain Relevance 1.07
This view, however, appeared to be incorrect for the following reasons: (1) In radioligand binding studies urapidil did not show any affinity for alpha 2 adrenoceptors; and (2) the central hypotensive activity of urapidil, injected into feline vertebral arteries remained unaffected by the alpha 2-adrenoceptor-blocking agents yohimbine and rauwolscine, which are known to suppress the central hypotensive effect of clonidine.
alpha 2 Binding (affinity) of in vertebral arteries associated with hypotension and clonidine
17) Confidence 0.24 Published 1989 Journal Am. J. Cardiol. Section Abstract Doc Link 2569262 Disease Relevance 0.41 Pain Relevance 0.29
Cross-tolerance between mu opioid and alpha-2 adrenergic receptors, but not between mu and delta opioid receptors in the spinal cord of the rat.
alpha-2 Binding (Cross-tolerance) of in spinal cord associated with tolerance, delta opioid receptors, opioid and spinal cord
18) Confidence 0.21 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 8098759 Disease Relevance 0.15 Pain Relevance 1.19
Discriminative stimulus properties of the vasodilator, hydralazine: differential generalization with alpha 1 and alpha 2 adrenoreceptor drugs.
alpha 2 Binding (generalization) of
19) Confidence 0.20 Published 1982 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Title Doc Link 6287529 Disease Relevance 0.06 Pain Relevance 0.15
The 60 day-old offspring showed only a reduced alpha 2 binding which appeared to have no regional specificity.
alpha 2 Spec (appeared) Binding (binding) of
20) Confidence 0.18 Published 1984 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 6494211 Disease Relevance 0.31 Pain Relevance 0.17

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