INT184890

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2010
Negated 4
Speculated 3
Reported most in Body
Documents 35
Total Number 38
Disease Relevance 44.35
Pain Relevance 13.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MCRS1) protein modification process (MCRS1) nucleolus (MCRS1)
nucleus (MCRS1) cytoplasm (MCRS1)
Anatomy Link Frequency
blood 1
spike 1
Cranial 1
brain stem 1
optic 1
MCRS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 3902 100.00 Very High Very High Very High
ketamine 13 100.00 Very High Very High Very High
imagery 231 99.92 Very High Very High Very High
Versed 15 98.56 Very High Very High Very High
addiction 3 97.40 Very High Very High Very High
alcohol 26 96.96 Very High Very High Very High
ischemia 61 94.08 High High
medulla 10 91.20 High High
cytokine 86 85.24 High High
Pain 15 83.64 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 2658 100.00 Very High Very High Very High
Intracranial Hypertension 395 100.00 Very High Very High Very High
Death 247 99.92 Very High Very High Very High
Brain Injury 844 99.84 Very High Very High Very High
Injury 465 99.84 Very High Very High Very High
Hematoma 288 99.72 Very High Very High Very High
Emergencies 49 99.72 Very High Very High Very High
Hypothermia 57 99.60 Very High Very High Very High
Hydrocephalus 78 99.52 Very High Very High Very High
Sleep Disorders 160 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Variation in StcO2 and BIS are associated with changes in ICP and CPP.
Regulation (changes) of ICP associated with cva
1) Confidence 0.22 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.29 Pain Relevance 0.58
The residuals used in the logistic models for ICP, HD and EHR were, at a regional level, the signed deviance residuals, given by:

where y is the number of observed event (ICP, HD or EHR) in the region and ?

Regulation (number) of ICP associated with death
2) Confidence 0.20 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.42 Pain Relevance 0
The moderate degree of clinical certainty, the nebulous recommendation to initiate treatment, and the ICP range indicate that a precise ICP endpoint has not been realized.
Neg (not) Regulation (realized) of ICP associated with cva
3) Confidence 0.18 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.12 Pain Relevance 0.53
The dual primary aims of this study were to validate and calibrate a novel portable venous ophthalmodynamometer and then use it to non-invasively estimate ICP values in subjects at various altitudes, a test of the physiologic response to hypobaric hypoxemia.
Regulation (values) of ICP associated with cva
4) Confidence 0.17 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2987855 Disease Relevance 1.18 Pain Relevance 0.28
The vODM was calibrated against actual ICP in 12 neurosurgical patients, most affected with acute hydrocephalus and monitored using ventriculostomy/pressure transducers.
Regulation (affected) of ICP associated with hydrocephalus and cva
5) Confidence 0.17 Published 2010 Journal BMC Neurol Section Abstract Doc Link PMC2987855 Disease Relevance 1.26 Pain Relevance 0.35
Secondary objectives intended to determine if the proximity of a specialized cardiology center influences the ICP, HD, LoS and EHR.
Regulation (influences) of ICP associated with death
6) Confidence 0.14 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.98 Pain Relevance 0
What is less known is the effect ICP may have on HD, LoS and EHR, and how this effect may vary from one region to another.
Spec (may) Regulation (have) of ICP associated with death
7) Confidence 0.12 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 1.26 Pain Relevance 0.06
CAP Index has an additional association with survival, good neurological outcome, and lack of need for interventions to lower ICP, independent of ICP and CPP.
Neg (independent) Regulation (independent) of ICP associated with cva
8) Confidence 0.11 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.29 Pain Relevance 0.55
There are 1,883 concurrent, hourly observations of ICP, CPP, BIS and StcO2 values.
Regulation (values) of ICP associated with cva
9) Confidence 0.11 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.77 Pain Relevance 0.31
ICP was continuously measured in TBI patients via an intraparenchymal probe (Codman & Shurlett Inc., Ryanham, MA, USA) inserted into the frontal lobe via Technicam Cranial Access® device (Technicam Ltd, Newton Abbot, UK) by a neurosurgeon.
Regulation (measured) of ICP in Cranial associated with cva and brain injury
10) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2592740 Disease Relevance 1.22 Pain Relevance 0.59
However, experimental studies clearly show that oedema of the optic disk requires a few days to develop and resolve, making it a less useful clinical sign in settings where there may be acute increases or dynamic changes in ICP [26].
Regulation (changes) of ICP in optic associated with pressure and volume under development and cva
11) Confidence 0.10 Published 2008 Journal Crit Care Section Body Doc Link PMC2592740 Disease Relevance 1.45 Pain Relevance 0.63
ICP was measured invasively during the MRI scan via a parenchymal sensor in the TBI patients.


Regulation (measured) of ICP associated with cva, imagery and brain injury
12) Confidence 0.10 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2592740 Disease Relevance 1.24 Pain Relevance 0.73
The ICP, MAP, BIS, and StcO2 values were recorded hourly for each of the first six post-injury days.
Regulation (values) of ICP associated with injury and cva
13) Confidence 0.10 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.23 Pain Relevance 0.29
Full-time surgical intensivists (four) and neurosurgeons (three) managed all patients and ordered interventions based on hourly ICP and CPP values.
Regulation (values) of ICP associated with cva
14) Confidence 0.10 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.44 Pain Relevance 0.08
ICP monitoring is, therefore, commonly implemented in patients with neurologic injury and a high risk of developing intracranial hypertension, in order to detect changes in ICP in a timely manner and to induce therapeutic interventions [2].
Regulation (changes) of ICP associated with injury and cva
15) Confidence 0.06 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2936928 Disease Relevance 1.44 Pain Relevance 0.41
No change in ICP was defined as an ICP level of ?
Neg (No) Regulation (change) of ICP associated with cva
16) Confidence 0.06 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2853529 Disease Relevance 1.35 Pain Relevance 0.35
In the pentobarbital and thiopental groups, ICP was controlled in 18% and 50% of patients, respectively, without any statistically significant difference between groups in the rate of infectious complications or hemodynamic compromise.
Regulation (controlled) of ICP associated with cva
17) Confidence 0.06 Published 2008 Journal Crit Care Section Body Doc Link PMC2592754 Disease Relevance 0.94 Pain Relevance 0.21
Forty-four patients were randomly assigned to receive pentobarbital or thiopental after first-level measures had failed to control ICP.
Neg (failed) Regulation (control) of ICP associated with cva
18) Confidence 0.05 Published 2008 Journal Crit Care Section Body Doc Link PMC2592754 Disease Relevance 0.95 Pain Relevance 0.21
20 mm Hg throughout the study period (relative immunoreactivity: healthy volunteers = 100.0 ┬▒ 16.96%, ICP ?
Regulation (volunteers) of ICP associated with cva
19) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2853529 Disease Relevance 0.85 Pain Relevance 0.37
Although it appears that the initial ICP values in the ICP ?
Spec (appears) Regulation (values) of ICP associated with cva
20) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2853529 Disease Relevance 1.89 Pain Relevance 0.81

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