INT184895

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 46
Total Number 47
Disease Relevance 56.03
Pain Relevance 19.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MCRS1) protein modification process (MCRS1) nucleolus (MCRS1)
nucleus (MCRS1) cytoplasm (MCRS1)
Anatomy Link Frequency
brain 4
spikes 2
blood 1
MCRS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 4810 100.00 Very High Very High Very High
imagery 171 99.84 Very High Very High Very High
cytokine 218 92.08 High High
tolerance 3 91.84 High High
epidural 26 80.20 Quite High
alcohol 22 71.72 Quite High
Inflammation 144 70.36 Quite High
ischemia 15 60.80 Quite High
agonist 27 53.68 Quite High
Pain 6 53.20 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 4296 100.00 Very High Very High Very High
Intracranial Hypertension 457 100.00 Very High Very High Very High
Death 305 100.00 Very High Very High Very High
Brain Injury 1802 99.84 Very High Very High Very High
Injury 1055 99.30 Very High Very High Very High
Cerebral Haemorrage 24 99.28 Very High Very High Very High
Cerebral Hypoxia 65 98.88 Very High Very High Very High
Sleep Disorders 95 97.60 Very High Very High Very High
Intracranial Hypotension 8 97.24 Very High Very High Very High
Pressure Volume 2 Under Development 90 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prediction of actual ICP
Gene_expression (Prediction) of ICP associated with cva
1) Confidence 0.42 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2987855 Disease Relevance 0.49 Pain Relevance 0.17
These properties make the prediction of ICP in absolute mm Hg possible.
Gene_expression (prediction) of ICP associated with cva
2) Confidence 0.42 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2987855 Disease Relevance 1.03 Pain Relevance 0.20
The residuals used in the logistic models for ICP, HD and EHR were, at a regional level, the signed deviance residuals, given by:

where y is the number of observed event (ICP, HD or EHR) in the region and ?

Gene_expression (models) of ICP associated with death
3) Confidence 0.30 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.41 Pain Relevance 0
Multiple regression analyses (Table 2) show that the presence of an ICP is correlated with an increased LoS, but with a decreased HD and EHR rates.
Gene_expression (presence) of ICP associated with death
4) Confidence 0.30 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.40 Pain Relevance 0
The residuals used in the logistic models for ICP, HD and EHR were, at a regional level, the signed deviance residuals, given by:

where y is the number of observed event (ICP, HD or EHR) in the region and ?

Gene_expression (models) of ICP associated with death
5) Confidence 0.30 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.43 Pain Relevance 0
Beyond age and gender, the potential predictors of the average log-transformation of LoS, the HD rate and the EHR rate were the presence of an ICP and the distance to a specialized cardiology center.
Gene_expression (presence) of ICP associated with death
6) Confidence 0.30 Published 2005 Journal BMC Cardiovasc Disord Section Body Doc Link PMC1181243 Disease Relevance 0.19 Pain Relevance 0
We therefore undertook a retrospective analysis of MRI scans in a cohort of TBI patients with ICP monitoring in order to study the relationship between ONSD and ICP and to assess the diagnosis accuracy of ONSD for the detection of raised ICP.
Gene_expression (detection) of ICP associated with cva, imagery and brain injury
7) Confidence 0.25 Published 2008 Journal Crit Care Section Body Doc Link PMC2592740 Disease Relevance 1.50 Pain Relevance 0.74
A significant and strong linear relationship was found between ONSD and ICP (r = 0.71, P < 0.0001; Figure 2a).
Gene_expression (found) of ICP associated with cva
8) Confidence 0.25 Published 2008 Journal Crit Care Section Body Doc Link PMC2592740 Disease Relevance 1.60 Pain Relevance 0.54
The ONSD was significantly higher in TBI patients with raised ICP (>20 mmHg; 6.31 ± 0.50 mm, n = 19) than in TBI patients with ICP of ?
Gene_expression (raised) of ICP associated with cva and brain injury
9) Confidence 0.25 Published 2008 Journal Crit Care Section Body Doc Link PMC2592740 Disease Relevance 1.18 Pain Relevance 0.26
The moderate degree of clinical certainty, the nebulous recommendation to initiate treatment, and the ICP range indicate that a precise ICP endpoint has not been realized.
Gene_expression (range) of ICP associated with cva
10) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.12 Pain Relevance 0.53
ICP, CPP, BIS and StcO2 rates are: ICP ?
Gene_expression (rates) of ICP associated with cva
11) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.80 Pain Relevance 0.36
The ICP, MAP, BIS, and StcO2 values were recorded hourly for each of the first six post-injury days.
Gene_expression (values) of ICP associated with injury and cva
12) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.23 Pain Relevance 0.29
Primary interventions for patients with ICP >20 torr included: brain CT scan to detect surgical lesions and the need for craniotomy, sedation when MAP ?
Gene_expression (>20) of ICP in brain associated with cva and sleep disorders
13) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.89 Pain Relevance 0.17
ICP, CPP, BIS and StcO2 rates are: ICP ?
Gene_expression (rates) of ICP associated with cva
14) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 0.80 Pain Relevance 0.36
With a BIS <60 and StcO2 <70 an ICP monitor is indicated.
Gene_expression (monitor) of ICP associated with cva
15) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.90 Pain Relevance 0.55
During preliminary data analyses the ICP to CPP ratio (ICP/(MAP - ICP)) was found to be highly discriminate for surviving and non-surviving patients.
Gene_expression (/) of ICP associated with cva
16) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.18 Pain Relevance 0.33
During preliminary data analyses the ICP to CPP ratio (ICP/(MAP - ICP)) was found to be highly discriminate for surviving and non-surviving patients.
Gene_expression (/) of ICP associated with cva
17) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.19 Pain Relevance 0.33
Further indication that ICP and CPP targets are unclear is the controversy between CPP versus ICP management [13-15] Additionally, CPP does not equate to cerebral blood flow [5].
Gene_expression (management) of ICP in blood associated with cva
18) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.06 Pain Relevance 0.53
During preliminary data analyses the ICP to CPP ratio (ICP/(MAP - ICP)) was found to be highly discriminate for surviving and non-surviving patients.
Gene_expression (/) of ICP associated with cva
19) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.18 Pain Relevance 0.33
BIS, StcO2, ICP, and CPP are related, but distinct indices of outcome with severe brain injury.
Gene_expression (related) of ICP in brain associated with cva and brain injury
20) Confidence 0.24 Published 2006 Journal Crit Care Section Body Doc Link PMC1794465 Disease Relevance 1.38 Pain Relevance 0.57

General Comments

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