INT1849

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 1975
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 14
Total Number 16
Disease Relevance 0.95
Pain Relevance 5.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SUPT7L)
Anatomy Link Frequency
brain 1
VLM 1
SUPT7L (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 8 100.00 Very High Very High Very High
Clonidine 7 100.00 Very High Very High Very High
medulla 6 100.00 Very High Very High Very High
cINOD 2 100.00 Very High Very High Very High
Paracetamol 2 100.00 Very High Very High Very High
antagonist 5 99.98 Very High Very High Very High
opioid receptor 7 99.76 Very High Very High Very High
agonist 9 99.68 Very High Very High Very High
Inflammatory response 1 98.92 Very High Very High Very High
Enkephalin 16 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 100.00 Very High Very High Very High
Toxocariasis 4 100.00 Very High Very High Very High
Nociception 1 89.28 High High
Sleep Disorders 1 77.88 Quite High
Pressure Volume 2 Under Development 1 77.20 Quite High
Cv General 3 Under Development 1 45.76 Quite Low
Heart Disease 1 42.48 Quite Low
Coronary Artery Disease 1 34.00 Quite Low
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moxonidine inhibited [3H]clonidine binding to bovine VLM membranes in a heterogeneous manner, showing 40-fold selectivity for one component.
bovine Binding (binding) of in VLM associated with medulla and clonidine
1) Confidence 0.47 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8380858 Disease Relevance 0.42 Pain Relevance 0.37
Cysteinyldopaenkephalins: synthesis, characterization and binding to bovine brain opioid receptors.
bovine Binding (binding) of in brain associated with enkephalin and opioid receptor
2) Confidence 0.47 Published 2000 Journal Biochim. Biophys. Acta Section Title Doc Link 10719171 Disease Relevance 0 Pain Relevance 0.57
We have examined the interaction of tertiary amine local anesthetics with the bovine hippocampal serotonin1A (5-HT1A) receptor, an important member of the G-protein-coupled receptor superfamily. 2.
bovine Spec (examined) Binding (interaction) of associated with local anesthetic
3) Confidence 0.47 Published 2004 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 15206822 Disease Relevance 0 Pain Relevance 0.54
The obtained pattern of biphasic interaction bore a marked resemblance to reported Scatchard plots representing the interaction of drugs with bovine serum albumin, and depicting two components of widely differing binding affinity and capacity.
bovine Binding (interaction) of
4) Confidence 0.47 Published 1983 Journal Life Sci. Section Abstract Doc Link 6865650 Disease Relevance 0 Pain Relevance 0
There was a significant decrease in lipophilicity resulting from glycosylation and a slight reduction in binding to bovine serum albumin.
bovine Binding (binding) of
5) Confidence 0.47 Published 2000 Journal Brain Res. Section Abstract Doc Link 11033091 Disease Relevance 0.09 Pain Relevance 0.64
Kinetic evidence for differential agonist and antagonist binding to bovine hippocampal synaptic membrane opioid receptors.
bovine Binding (binding) of associated with antagonist, agonist and opioid receptor
6) Confidence 0.47 Published 1984 Journal J. Biol. Chem. Section Title Doc Link 6092373 Disease Relevance 0 Pain Relevance 1.12
In addition, phenoxybenzamine showed little or no calcium-dependent binding to the S-100 protein, bovine serum albumin or cytochrome c.
bovine Binding (binding) of
7) Confidence 0.36 Published 1988 Journal Biochem. Pharmacol. Section Abstract Doc Link 3134891 Disease Relevance 0 Pain Relevance 0.09
Rotational behaviour produced by intranigral injections of bovine and human beta-casomorphins in rats.
bovine Binding (injections) of
8) Confidence 0.36 Published 1989 Journal Psychopharmacology (Berl.) Section Title Doc Link 2556724 Disease Relevance 0 Pain Relevance 0.53
Anaerobic spectroscopy reveals binding of substrates (spermidine and benzylamine) and of an imidazoline site ligand (clonidine) to the reduced active site of bovine SSAO, whereas interactions with oxidized enzyme are evident in kinetic assays and crystallization studies.
bovine Spec (evident) Binding (binding) of associated with clonidine
9) Confidence 0.36 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 17989349 Disease Relevance 0.08 Pain Relevance 0.26
This tissue was mounted in vitro in an Ussing-style chamber with fresh water on the mucosal surface and saline supplemented with bovine serum albumin on the serosal surface.
bovine Binding (supplemented) of
10) Confidence 0.36 Published 1992 Journal J. Exp. Biol. Section Abstract Doc Link 1602278 Disease Relevance 0 Pain Relevance 0.08
Anti-bovine aFGF rabbit IgG was conjugated with N-hydroxysuccimidobiotin, and the resulting IgG-biotin conjugate was used as the second antibody.
bovine Binding (conjugated) of
11) Confidence 0.36 Published 1999 Journal Clin. Chim. Acta Section Abstract Doc Link 10404741 Disease Relevance 0 Pain Relevance 0
The sequence of the hepatapeptide identified it as a fragment of bovine beta-casein.
bovine Binding (fragment) of
12) Confidence 0.36 Published 1979 Journal Hoppe-Seyler's Z. Physiol. Chem. Section Abstract Doc Link 511111 Disease Relevance 0 Pain Relevance 0.42
Many compounds including bovine superoxide dismutase, non steroidal anti-inflammatory drugs, radical scavengers (e.g. acetaminophen), corticoids etc., have been shown to counteract this phenomenon.
bovine Binding (counteract) of associated with paracetamol, inflammation and cinod
13) Confidence 0.36 Published 1984 Journal Life Sci. Section Abstract Doc Link 6422176 Disease Relevance 0.36 Pain Relevance 0.33
A glucose amperometric biosensor based on glucose oxidase immobilized on an overoxidized polypyrrole (PPyox) platinum modified electrode, by glutaraldehyde co-crosslinking with bovine serum albumine, is described.
bovine Binding (crosslinking) of
14) Confidence 0.35 Published 1998 Journal Biosens Bioelectron Section Abstract Doc Link 9519453 Disease Relevance 0 Pain Relevance 0.07
[Studies on the binding of some parasympatholytics to bovine serum albumin/measurement of relaxation times (author's transl)].
bovine Binding (binding) of
15) Confidence 0.35 Published 1975 Journal Arzneimittelforschung Section Title Doc Link 241353 Disease Relevance 0 Pain Relevance 0.09
Non-specific binding of bovine serum albumin is moreover very low because of the repellent polymer.
bovine Binding (binding) of
16) Confidence 0.35 Published 2008 Journal Biosens Bioelectron Section Abstract Doc Link 18718754 Disease Relevance 0 Pain Relevance 0.32

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox