INT184922

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.18
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Th) mitochondrion (Th) oxidoreductase activity (Th)
nucleus (Th) cytoplasm (Th)
Anatomy Link Frequency
brain 2
Th (Mus musculus)
da (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 200 100.00 Very High Very High Very High
monoamine 14 91.72 High High
Serotonin 3 69.68 Quite High
addiction 2 48.04 Quite Low
agonist 12 5.00 Very Low Very Low Very Low
Eae 5 5.00 Very Low Very Low Very Low
Ventral tegmentum 3 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Nucleus accumbens 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 33 96.12 Very High Very High Very High
Pathologic Processes 2 23.04 Low Low
Tremor 10 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 9 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 4 5.00 Very Low Very Low Very Low
Catalepsy 4 5.00 Very Low Very Low Very Low
Drug Dependence 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Hypokinesia 1 5.00 Very Low Very Low Very Low
Sleep Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We report here that the pharmacologic inhibition of the rate-limiting enzyme of DA synthesis, TH, almost immediately depletes brain DA to undetectable levels in DAT-KO mice and induces a transient recapitulation of essentially all PD symptoms for up to 16 h.
Negative_regulation (inhibition) of TH in brain Negative_regulation (depletes) of DA associated with parkinson's disease and dopamine
1) Confidence 0.12 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.18 Pain Relevance 0.52

General Comments

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