INT18495

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Context Info
Confidence 0.19
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 4.79
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Bad) cell proliferation (Bad) cytosol (Bad)
mitochondrion (Bad) cytoplasm (Bad)
Anatomy Link Frequency
cleavage 1
uterine 1
Bad (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 16 100.00 Very High Very High Very High
Antinociceptive 1 93.00 High High
Hippocampus 8 92.16 High High
antagonist 1 90.56 High High
Spinal cord 66 89.68 High High
Clonidine 4 88.40 High High
noradrenaline 1 86.56 High High
Potency 2 84.96 Quite High
Kappa opioid receptor 1 68.52 Quite High
headache 1 60.72 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 181 100.00 Very High Very High Very High
Stress 55 99.68 Very High Very High Very High
Injury 20 99.08 Very High Very High Very High
Uterine Fibroids 5 98.84 Very High Very High Very High
Increased Venous Pressure Under Development 8 98.08 Very High Very High Very High
Parkinson's Disease 6 96.88 Very High Very High Very High
Death 43 94.12 High High
Metastasis 14 89.72 High High
Recurrence 13 88.16 High High
Body Weight 85 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, taurine treatment inhibited As-induced up-regulation of Bad, Bax and down-regulation of Bcl-2, Bcl-xL.
Regulation (regulation) of Bad
1) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.71 Pain Relevance 0
As caused mitochondrial injury by increased oxidative stress and reciprocal regulation of Bcl-2, Bcl-xL/Bad, Bax, Bim in association with increased level of Apaf-1, activation of caspase 9/3, cleavage of PARP protein and ultimately led to apoptotic cell death.
Regulation (regulation) of Bad in cleavage associated with stress, injury, apoptosis and death
2) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935368 Disease Relevance 0.86 Pain Relevance 0
We observed that NaAsO2 induced up-regulation of pro apoptotic (active non-phospho form of Bad, Bax) and down-regulation of anti apoptotic (active non-phospho form of Bcl-2, Bcl-xL) Bcl-2 family proteins both in vivo and in vitro (Fig. 5A, 5B, 5C, 5D).
Regulation (regulation) of Bad associated with apoptosis
3) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.91 Pain Relevance 0
Alpha 2-agonist-induced dilations were not modified by beta-blockade, which significantly suppressed isoprenaline-induced vasodilations.
Neg (not) Regulation (modified) of Alpha 2-agonist-induced associated with agonist
4) Confidence 0.06 Published 1990 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 1974660 Disease Relevance 0.58 Pain Relevance 0.75
AMJ and BAD were responsible for delivering patient care.
Regulation (responsible) of BAD
5) Confidence 0.06 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2902475 Disease Relevance 0.98 Pain Relevance 0
The kappa-agonist activity in both the 4-acyl and the 4-carbamate series is sensitive to the size of the 4-substituent.
Regulation (sensitive) of kappa-agonist associated with agonist
6) Confidence 0.05 Published 1993 Journal J. Med. Chem. Section Abstract Doc Link 8393489 Disease Relevance 0 Pain Relevance 0.32
They were transfected with recombinant adenoviruses to express constitutive active (CA) or dominant negative (DN) forms of RhoA, Rac1, or Cdc42 under the control of the CAG promoter, along with marker genes (?
Regulation (control) of CAG promoter
7) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2789715 Disease Relevance 0.32 Pain Relevance 0.21
Efficacy of a gonadotropin-releasing hormone agonist in the treatment of uterine leiomyomata: long-term follow-up.
Regulation (Efficacy) of agonist in uterine associated with uterine fibroids and agonist
8) Confidence 0.00 Published 1989 Journal Fertil. Steril. Section Title Doc Link 2498132 Disease Relevance 0.43 Pain Relevance 0.16

General Comments

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