INT184953

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.19
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDC6, PCNA) cytoplasm (CDC6, PCNA) nucleus (CDC6, PCNA)
DNA binding (PCNA) cell proliferation (PCNA) cytosol (CDC6)
CDC6 (Homo sapiens)
PCNA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 2 96.88 Very High Very High Very High
withdrawal 2 94.12 High High
metalloproteinase 2 41.60 Quite Low
cytokine 1 36.76 Quite Low
psoriasis 3 15.60 Low Low
Paracetamol 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 96.88 Very High Very High Very High
Skin Cancer 4 90.48 High High
Cancer 23 50.00 Quite Low
Breast Cancer 2 24.64 Low Low
Psoriasis 5 17.68 Low Low
Apoptosis 8 5.00 Very Low Very Low Very Low
Colon Cancer 8 5.00 Very Low Very Low Very Low
Repression 3 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cdc-6, which are regulated in response to mitogenic signals, binds PCNA and is required for initiation of DNA replication [34], was also repressed at both 12 and 24 hrs after NAC treatment, implying programs involving withdrawal of mitogenic factors as important mechanisms for NAC mediated inhibition of proliferation and increased differentiation in NHEK cells.
Cdc-6 Binding (binds) of PCNA associated with withdrawal
1) Confidence 0.05 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.19 Pain Relevance 0.13

General Comments

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