INT184977

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.38
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HGS) endosome (HGS) signal transduction (HGS)
cytoplasm (HGS)
Anatomy Link Frequency
blood 1
Caco-2 1
HGS (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 4 98.00 Very High Very High Very High
Inflammation 4 91.40 High High
metalloproteinase 4 49.36 Quite Low
cytokine 2 31.28 Quite Low
psoriasis 6 10.12 Low Low
Paracetamol 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 6 100.00 Very High Very High Very High
Hypercholesterolemia 3 99.62 Very High Very High Very High
Cardiovascular Disease 23 98.90 Very High Very High Very High
Obesity 7 98.28 Very High Very High Very High
Nicotine Addiction 8 98.18 Very High Very High Very High
INFLAMMATION 4 91.40 High High
Colon Cancer 16 89.04 High High
Skin Cancer 8 85.00 Quite High
Apoptosis 16 80.88 Quite High
Disease 7 58.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further adjustment for traditional risk factors, such as smoking, BMI, parental history of early CVD, self-reported elevated cholesterol and blood glucose attenuated the HRs slightly, but they nevertheless remained clearly significant.
Negative_regulation (attenuated) of HRs in blood associated with nicotine addiction, cardiovascular disease, obesity and hypercholesterolemia
1) Confidence 0.28 Published 2008 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2259296 Disease Relevance 0.73 Pain Relevance 0
When investigating Cox-2 expression by RT-PCR we could confirm the down-regulation at 24 hrs in Caco-2 and identify an additional repression in NHEK at 1, 3 and 48 hrs after NAC treatment.
Negative_regulation (repression) of hrs in Caco-2 associated with repression
2) Confidence 0.13 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.47 Pain Relevance 0
Cdc-6, which are regulated in response to mitogenic signals, binds PCNA and is required for initiation of DNA replication [34], was also repressed at both 12 and 24 hrs after NAC treatment, implying programs involving withdrawal of mitogenic factors as important mechanisms for NAC mediated inhibition of proliferation and increased differentiation in NHEK cells.
Negative_regulation (repressed) of hrs associated with withdrawal
3) Confidence 0.13 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.18 Pain Relevance 0.13

General Comments

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