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Context Info
Confidence 0.26
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.43
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TFF3) proteinaceous extracellular matrix (TFF3) molecular_function (TFF3)
Anatomy Link Frequency
Caco-2 1
TFF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
psoriasis 3 88.00 High High
metalloproteinase 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometrial Cancer 153 97.28 Very High Very High Very High
Psoriasis 5 88.00 High High
Apoptosis 24 79.48 Quite High
Colon Cancer 16 75.72 Quite High
Congenital Anomalies 2 72.52 Quite High
Aneuploidy 3 57.60 Quite High
Malignant Neoplastic Disease 18 56.32 Quite High
Cancer 108 50.00 Quite Low
Adenocarcinoma 6 46.44 Quite Low
Endometrial Hyperplasia 4 45.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In Caco-2 the up-regulation of AQP3, NDRG1 and TFF3 were among the genes that validated the results from the global transcription profile analysis.
Regulation (regulation) of TFF3 in Caco-2
1) Confidence 0.26 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.23 Pain Relevance 0.07
Intestinal trefoil protein, TFF3, AGR2 developmental gene, estrogen-regulated genes (MGB2, LTF, END1, MMP11), FOXA2, and MSX2 were significantly up-regulated in endometrioid endometrial carcinomas, while increased expression of FOLR, genes involved in the regulation of mitotic spindle checkpoint (STK15, BUB1, CCNB2), IGF2, PTGS1 and p16 were seen in non-endometrioid endometrial carcinomas.
Regulation (regulated) of TFF3 associated with endometrial cancer
2) Confidence 0.20 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.20 Pain Relevance 0

General Comments

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