INT184987

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.27
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDC6) nucleoplasm (CDC6) mitosis (CDC6)
nucleus (CDC6) cell division (CDC6) cytoplasm (CDC6)
CDC6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 3 96.88 Very High Very High Very High
withdrawal 2 92.32 High High
qutenza 130 66.00 Quite High
metalloproteinase 2 38.00 Quite Low
cytokine 1 36.76 Quite Low
psoriasis 3 15.60 Low Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 3 96.88 Very High Very High Very High
Skin Cancer 4 90.48 High High
Small Cell Lung Cancer 63 84.32 Quite High
Cancer 65 50.00 Quite Low
Lung Cancer 10 30.08 Quite Low
Breast Cancer 4 24.64 Low Low
Psoriasis 5 17.68 Low Low
Apoptosis 14 5.00 Very Low Very Low Very Low
Colon Cancer 8 5.00 Very Low Very Low Very Low
Metastasis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These free E2Fs subsequently bind to target proliferative promoters like cyclin E, thymidylate synthase (TS), cdc25A and cdc6, which regulate cell cycle progression [31], [32].
Regulation (target) of cdc6
1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.08 Pain Relevance 0.12
Cdc-6, which are regulated in response to mitogenic signals, binds PCNA and is required for initiation of DNA replication [34], was also repressed at both 12 and 24 hrs after NAC treatment, implying programs involving withdrawal of mitogenic factors as important mechanisms for NAC mediated inhibition of proliferation and increased differentiation in NHEK cells.
Regulation (regulated) of Cdc-6 associated with withdrawal
2) Confidence 0.07 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.19 Pain Relevance 0.13

General Comments

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