INT184989

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.77
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDKN2B) nucleus (CDKN2B) kinase activity (CDKN2B)
cytoplasm (CDKN2B)
CDKN2B (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 73.28 Quite High
Bioavailability 18 5.00 Very Low Very Low Very Low
Potency 12 5.00 Very Low Very Low Very Low
psoriasis 6 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
anticonvulsant 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Myeloid Leukemia 3 99.96 Very High Very High Very High
Myeloid Leukemia 138 95.16 Very High Very High Very High
Myelodysplastic Syndromes 174 94.84 High High
Recurrence 9 94.76 High High
Cancer 187 85.80 High High
Apoptosis 55 79.80 Quite High
Targeted Disruption 2 71.52 Quite High
Repression 9 68.20 Quite High
Disease 35 66.88 Quite High
Fever 15 66.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As an example, up-regulation in NHEK after 24 hrs was seen for transcripts encoding CDKN2B (p15), which is believed to be an effector of TGF-?
Positive_regulation (believed) of p15
1) Confidence 0.47 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.44 Pain Relevance 0.04
As an example, up-regulation in NHEK after 24 hrs was seen for transcripts encoding CDKN2B (p15), which is believed to be an effector of TGF-?
Positive_regulation (believed) of CDKN2B
2) Confidence 0.47 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.44 Pain Relevance 0.04
Furthermore in acute myelogenous leukemia, increased p15 methylation levels were found in CD34+ cells of many leukemic patients in haematological remission and was associated with a high relapse rate and significantly reduced relapse-free survival [46].
Positive_regulation (increased) of p15 associated with acute myeloid leukemia and recurrence
3) Confidence 0.44 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 1.09 Pain Relevance 0
Although a modest but significant increment on p15 and p21 mRNA expression was detected, this was not associated with clinical response.
Positive_regulation (increment) of p15
4) Confidence 0.44 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.26 Pain Relevance 0
Reexpression of p15 protein was increased and correlated with clinical response.
Positive_regulation (increased) of p15
5) Confidence 0.41 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 0.55 Pain Relevance 0

General Comments

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