INT184992

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.70
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDC6) nucleoplasm (CDC6) mitosis (CDC6)
nucleus (CDC6) cell division (CDC6) cytoplasm (CDC6)
Anatomy Link Frequency
H69 1
CDC6 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 260 99.72 Very High Very High Very High
Inflammation 4 96.88 Very High Very High Very High
withdrawal 2 94.76 High High
metalloproteinase 2 42.88 Quite Low
cytokine 1 36.76 Quite Low
Pain 2 17.60 Low Low
psoriasis 3 15.60 Low Low
Paracetamol 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 126 98.40 Very High Very High Very High
INFLAMMATION 4 96.88 Very High Very High Very High
Skin Cancer 4 90.48 High High
Breast Cancer 6 77.28 Quite High
Reprotox - General 1 8 57.12 Quite High
Squamous Cell Carcinoma 2 56.08 Quite High
Cancer 107 51.32 Quite High
Apoptosis 20 48.52 Quite Low
Stomach Cancer 4 39.64 Quite Low
Anaplastic Astrocytoma 2 38.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
E2F1, E2F2 and E2F3 are often referred to as “activator” E2Fs because they transcriptionally activate E2F target proliferative genes such as cyclin E, cdc25A and cdc6 [25], [27], [28], [29].
Positive_regulation (activate) of cdc6
1) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.24 Pain Relevance 0.34
Therefore, ChIP assays were performed to examine the differential occupancy of E2F family of proteins on E2F-responsive proliferative promoters (cyclin E, TS, cdc25A and cdc6) upon capsaicin-treatment of H69 human SCLC cells [31], [32], [40], [45].
Spec (examine) Positive_regulation (occupancy) of cdc6 in H69 associated with qutenza and small cell lung cancer
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.28 Pain Relevance 0.49
Cdc-6, which are regulated in response to mitogenic signals, binds PCNA and is required for initiation of DNA replication [34], was also repressed at both 12 and 24 hrs after NAC treatment, implying programs involving withdrawal of mitogenic factors as important mechanisms for NAC mediated inhibition of proliferation and increased differentiation in NHEK cells.
Positive_regulation (required) of Cdc-6 associated with withdrawal
3) Confidence 0.13 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.19 Pain Relevance 0.13

General Comments

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