INT184997

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Context Info
Confidence 0.63
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.65
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TOP2A) nuclear chromosome (TOP2A) aging (TOP2A)
chromosome segregation (TOP2A) enzyme binding (TOP2A) DNA binding (TOP2A)
Anatomy Link Frequency
internal 2
TOP2A (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 2 94.40 High High
Inflammation 2 82.16 Quite High
metalloproteinase 2 68.24 Quite High
cytokine 1 22.04 Low Low
tolerance 9 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
Dysuria 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
pain flank 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fever 42 99.74 Very High Very High Very High
Breast Cancer 30 98.36 Very High Very High Very High
Repression 4 96.04 Very High Very High Very High
Stomach Cancer 47 91.96 High High
Genomic Instability 1 84.96 Quite High
INFLAMMATION 2 82.16 Quite High
Cancer 86 77.88 Quite High
Skin Cancer 5 75.76 Quite High
Cystitis 7 75.20 Quite High
Urinary Tract Infection 27 73.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of Topoisomerase II (TOP2) was also repressed, confirming results obtained in NAC treated CHO cells [35].
Gene_expression (expression) of TOP2
1) Confidence 0.63 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.16 Pain Relevance 0.15
Unlike TOP2A, HER2 protein expression is not cell-cycle dependent, so other mechanisms (increased receptor degradation, transcriptional repression) may lay behind this discrepancy.
Gene_expression (expression) of TOP2A associated with repression
2) Confidence 0.24 Published 2011 Journal Pathology Research International Section Body Doc Link PMC3005843 Disease Relevance 1.07 Pain Relevance 0
For instance, the transfer of reverse gyrase from Archaea to some bacteria has probably helped their adaptation to extremely high temperature whereas the transfer of gyrase from Bacteria to some archaea has profoundly changed the internal topology of their DNA.
Gene_expression (transfer) of gyrase in internal associated with fever
3) Confidence 0.02 Published 2008 Journal Biol Direct Section Body Doc Link PMC2478661 Disease Relevance 0.10 Pain Relevance 0
It should be clear that we are not rejecting the notion that a certain proportion of phylogenetic incongruencies are due to HGT; even between Domains, the transfer of genes with pleiotropic effects (such as reverse gyrase or other topoisomerases [44,188] appears to have occurred, presumably under selection; this type of event seems however infrequent and contrasts with the indiscriminate recourse to HGT found in many publications.
Gene_expression (transfer) of gyrase
4) Confidence 0.02 Published 2008 Journal Biol Direct Section Body Doc Link PMC2478661 Disease Relevance 0 Pain Relevance 0
For instance, the transfer of reverse gyrase from Archaea to some bacteria has probably helped their adaptation to extremely high temperature whereas the transfer of gyrase from Bacteria to some archaea has profoundly changed the internal topology of their DNA.
Gene_expression (transfer) of gyrase in internal associated with fever
5) Confidence 0.02 Published 2008 Journal Biol Direct Section Body Doc Link PMC2478661 Disease Relevance 0.10 Pain Relevance 0
Plasmid-borne resistance has also recently been discovered, and is caused by protection of DNA gyrase and topoisomerase IV by Qnr-like proteins, including QnrA (Chenia et al 2006).
Gene_expression (protection) of DNA gyrase
6) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621400 Disease Relevance 0.22 Pain Relevance 0

General Comments

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