INT185

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Context Info
Confidence 0.54
First Reported 1977
Last Reported 2009
Negated 7
Speculated 2
Reported most in Abstract
Documents 18
Total Number 21
Disease Relevance 2.71
Pain Relevance 5.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Cyp1a1) mitochondrion (Cyp1a1) oxidoreductase activity (Cyp1a1)
aging (Cyp1a1) endoplasmic reticulum (Cyp1a1) enzyme binding (Cyp1a1)
Anatomy Link Frequency
liver 4
hepatocyte 2
Cyp1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
methadone 33 100.00 Very High Very High Very High
aspirin 12 100.00 Very High Very High Very High
cINOD 7 100.00 Very High Very High Very High
Lamotrigine 1 99.60 Very High Very High Very High
ketamine 3 99.54 Very High Very High Very High
Paracetamol 26 99.44 Very High Very High Very High
Gabapentin 1 98.96 Very High Very High Very High
carbamazepine 1 98.14 Very High Very High Very High
Analgesic 2 97.52 Very High Very High Very High
halothane 2 95.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 9 100.00 Very High Very High Very High
Breast Cancer 5 99.12 Very High Very High Very High
Diabetes Mellitus 1 98.38 Very High Very High Very High
Toxicity 9 98.08 Very High Very High Very High
Generalized Epilepsy 1 96.30 Very High Very High Very High
Epilepsy 11 95.12 Very High Very High Very High
Cancer 5 94.52 High High
Hepatotoxicity 3 85.20 High High
Syndrome 3 81.60 Quite High
Poisoning 1 77.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ketamine did not significantly affect CYP1 or CYP2B/2C activity.
Neg (not) Regulation (affect) of CYP1 associated with ketamine
1) Confidence 0.54 Published 1995 Journal Pharmacology Section Abstract Doc Link 7746831 Disease Relevance 0 Pain Relevance 0.28
It is found that guaiazulene inhibited considerably CYP1A2 and CYP2B1 and had a weak effect on CYP1A1 in rat hepatic microsomal fractions.
Regulation (effect) of CYP1A1
2) Confidence 0.47 Published 1997 Journal Arch. Pharm. (Weinheim) Section Abstract Doc Link 9112807 Disease Relevance 0.24 Pain Relevance 0.33
Acetylsalicylic acid and salicylic acid had no in vitro effect on the microsomal monooxygenase.
Neg (no) Regulation (effect) of microsomal monooxygenase associated with aspirin
3) Confidence 0.44 Published 1985 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 4042014 Disease Relevance 0.17 Pain Relevance 0.36
The PB-induced up-regulation of CYP2B, CYP2E1 and CYP1A1 isozymes was markedly higher in CD than in NF rats.
Regulation (regulation) of CYP1A1
4) Confidence 0.44 Published 2009 Journal J Appl Toxicol Section Abstract Doc Link 18798224 Disease Relevance 0 Pain Relevance 0.62
Gonadectomy altered the effect of methadone on epoxide hydratase, but not on aryl hydrocarbon hydroxylase activity, in both sexes.
Neg (not) Regulation (altered) of hydrocarbon hydroxylase associated with methadone
5) Confidence 0.37 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 445229 Disease Relevance 0 Pain Relevance 0.52
Effect of nonsteroidal anti-inflammatory drugs on the microsomal monooxygenase system of rat liver.
Regulation (Effect) of microsomal monooxygenase in liver associated with inflammation and cinod
6) Confidence 0.32 Published 1985 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 4042014 Disease Relevance 0.10 Pain Relevance 0.27
A sex difference was noted in the control levels of aryl hydrocarbon hydroxylase and glutathione S-transferase, but not of epoxide hydratase activity.
Neg (not) Regulation (control) of hydrocarbon hydroxylase
7) Confidence 0.27 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 445229 Disease Relevance 0 Pain Relevance 0.57
Caffeine (5 mM) also accelerated NAPQI formation in microsomes isolated from diabetic rats, but to a substantially lesser extent (120%), suggesting a modest (if any) effect on P-450IIE1, a form previously shown to form NAPQI from APAP.
Regulation (effect) of P-450IIE1 associated with paracetamol and diabetes mellitus
8) Confidence 0.24 Published 1991 Journal Drug Metab. Dispos. Section Abstract Doc Link 1676635 Disease Relevance 0.10 Pain Relevance 0.17
In contrast, when male rats were treated similarly, there was an increase in epoxide hydrase activity to 212% of controls with no change in aryl hydrocarbon hydroxylase activity.
Neg (no) Regulation (change) of aryl hydrocarbon hydroxylase
9) Confidence 0.23 Published 1977 Journal Drug Metab. Dispos. Section Abstract Doc Link 15816 Disease Relevance 0 Pain Relevance 0.28
The simultaneous treatment of the cocultures with phenobarbital and LPS (10 ng/ml) or 3-methylcholanthrene and LPS (10 ng/ml) resulted in a strong down-regulation (85%) of the phenobarbital-induced cytochrome P450 (CYP) isoform CYP2B1 in the hepatocytes whereas the 3-methylcholanthrene-induced isoform CYP1A1 was only weakly affected (15%).
Regulation (affected) of CYP1A1 in hepatocytes
10) Confidence 0.23 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10096772 Disease Relevance 0.22 Pain Relevance 0.08
HCl given in the drinking water for 4 weeks increased microsomal epoxide hydratase activity in the liver of adult male Wistar rats, with no change in aryl hydrocarbon hydroxylase activity.
Neg (no) Regulation (change) of hydrocarbon hydroxylase in liver
11) Confidence 0.16 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 445229 Disease Relevance 0 Pain Relevance 0.46
Gonadectomy altered the effect of methadone on epoxide hydratase, but not on aryl hydrocarbon hydroxylase activity, in both sexes.
Regulation (effect) of hydrocarbon hydroxylase associated with methadone
12) Confidence 0.16 Published 1979 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 445229 Disease Relevance 0 Pain Relevance 0.52
AhR, CYP1A1 and cdc42 mRNA expression were quantified in AhR by real-time PCR.
Regulation (quantified) of CYP1A1
13) Confidence 0.16 Published 2006 Journal Environ Health Section Body Doc Link PMC1570454 Disease Relevance 0 Pain Relevance 0
Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver were investigated in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content using monoclonal antibodies.
Regulation (regulation) of cytochrome P450IIE1 in liver
14) Confidence 0.13 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1602390 Disease Relevance 0 Pain Relevance 0.03
Sex-, age- and pregnancy-induced changes in the metabolism of toluene and trichloroethylene in rat liver in relation to the regulation of cytochrome P450IIE1 and P450IIC11 content.
Regulation (regulation) of cytochrome P450IIE1 in liver associated with analgesic
15) Confidence 0.13 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 1602390 Disease Relevance 0 Pain Relevance 0.16
We investigated the effects of the aspirin metabolite, salicylate (SA), on 7,12-dimethylbenz[a]anthracene (DMBA)-DNA adduct formation as well as on the expression of the enzymes involved in the carcinogen bioactivation pathway, in particular cytochrome P450 1A (CYP1A) and cyclooxygenases (COX-1 and COX-2).
Spec (investigated) Regulation (effects) of cytochrome P450 1A associated with aspirin
16) Confidence 0.12 Published 2006 Journal Int. J. Oncol. Section Abstract Doc Link 16596229 Disease Relevance 0.67 Pain Relevance 0.27
CYP1A1, a typical XRE-regulated gene, mRNA was induced without the application of ligand to the culture medium.
Regulation (regulated) of CYP1A1
17) Confidence 0.10 Published 2006 Journal Environ Health Section Abstract Doc Link PMC1570454 Disease Relevance 0.20 Pain Relevance 0.08
METHODS: We investigated the effect of incubation of rat hepatocytes and 3 hepatocyte cell lines with acetaminophen or N-acetyl-p-benzoquinoneimine on LDH release, glutathione status, mitochondrial function, CYP1A activity, albumin synthesis and DNA content.
Spec (investigated) Regulation (effect) of CYP1A in hepatocyte
18) Confidence 0.03 Published 1999 Journal J. Hepatol. Section Body Doc Link 10580581 Disease Relevance 0.10 Pain Relevance 0
Effects of D-limonene on hepatic microsomal monooxygenase activity and paracetamol-induced glutathione depletion in mouse.
Regulation (Effects) of microsomal monooxygenase associated with paracetamol
19) Confidence 0.01 Published 1993 Journal Xenobiotica Section Title Doc Link 8237062 Disease Relevance 0.09 Pain Relevance 0.10
Incubation of MTEP with expressed rat and human CYP isoforms showed that CYP1A and CYP2C isoforms are primarily responsible for the metabolism of this compound.
Regulation (responsible) of CYP1A
20) Confidence 0.01 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16153770 Disease Relevance 0.07 Pain Relevance 0.22

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