INT1850

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Context Info
Confidence 0.48
First Reported 1975
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 77
Total Number 81
Disease Relevance 7.61
Pain Relevance 15.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (OXA1L) protein complex assembly (OXA1L) protein complex (OXA1L)
Anatomy Link Frequency
plasma 7
erythrocytes 2
capillary 2
skin 2
liver 1
OXA1L (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 91 100.00 Very High Very High Very High
acular 43 100.00 Very High Very High Very High
Paracetamol 28 100.00 Very High Very High Very High
lidocaine 26 100.00 Very High Very High Very High
Analgesic 19 100.00 Very High Very High Very High
Inflammation 6 100.00 Very High Very High Very High
Clonidine 2 100.00 Very High Very High Very High
methadone 10 99.98 Very High Very High Very High
fluoxetine 4 99.76 Very High Very High Very High
methotrexate 28 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 69 100.00 Very High Very High Very High
Emergencies 6 99.80 Very High Very High Very High
Renal Failure 6 99.42 Very High Very High Very High
Angina 6 99.40 Very High Very High Very High
Cancer 27 98.60 Very High Very High Very High
Coronary Artery Disease 9 97.92 Very High Very High Very High
Cv General 3 Under Development 3 97.92 Very High Very High Very High
Myocardial Infarction 3 97.64 Very High Very High Very High
Toxicity 13 97.48 Very High Very High Very High
Breast Cancer 12 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Influence of octanoic acid on the reversible protein binding of ketorolac enantiomers to human serum albumin (HSA): comparative liquid chromatographic studies using a HSA chiral stationary phase.
HSA Binding (binding) of associated with acular
1) Confidence 0.48 Published 1994 Journal J. Chromatogr. B, Biomed. Appl. Section Title Doc Link 7894686 Disease Relevance 0 Pain Relevance 0.58
Because they are highly bound to human serum albumin (HSA), interferences between nonsteroidal anti-inflammatory drugs (NSAIDs) and coadministered drugs may arise from their interactions at a binding site on HSA.
HSA Binding (bound) of associated with inflammation and cinod
2) Confidence 0.47 Published 1995 Journal J Pharm Sci Section Abstract Doc Link 7500279 Disease Relevance 0.27 Pain Relevance 0.49
PURPOSE: This study was undertaken to investigate how fatty acids cause the allosteric binding of drugs to human serum albumin (HSA).
HSA Binding (binding) of
3) Confidence 0.45 Published 2002 Journal Pharm. Res. Section Abstract Doc Link 12425462 Disease Relevance 0 Pain Relevance 0.10
The binding of 1,6-dimethyl-3-carbethoxy-4-oxo-6,7,8,9-tetrahydro-homopyrimidazolium-methyl-sulfate (MZ 144, Probon) to human serum albumin (HSA) has been studied in vitro.
HSA Binding (binding) of
4) Confidence 0.45 Published 1975 Journal Arzneimittelforschung Section Abstract Doc Link 241355 Disease Relevance 0 Pain Relevance 0.07
The binding of representative chemical classes of nonsteroidal anti-inflammatory drugs (NSAIDs) to human serum albumin (HSA) was investigated by equilibrium dialysis.
HSA Binding (binding) of associated with inflammation and cinod
5) Confidence 0.45 Published 1988 Journal J Pharm Sci Section Abstract Doc Link 3373430 Disease Relevance 0.17 Pain Relevance 0.28
HSA is a heart-shaped protein composed of three homologous helical domains (I-III), which can be subdivided into two subdomains (A and B), and lidocaine binds to a unique site formed by residues from subdomain IB facing the central, interdomain crevice.
HSA Binding (binds) of in heart associated with lidocaine
6) Confidence 0.41 Published 2010 Journal J. Struct. Biol. Section Abstract Doc Link 20347991 Disease Relevance 0 Pain Relevance 0.53
Because they are highly bound to human serum albumin (HSA), interferences between nonsteroidal anti-inflammatory drugs (NSAIDs) and coadministered drugs may arise from their interactions at a binding site on HSA.
HSA Binding (interactions) of associated with inflammation and cinod
7) Confidence 0.41 Published 1995 Journal J Pharm Sci Section Abstract Doc Link 7500279 Disease Relevance 0.26 Pain Relevance 0.56
Although the percentage of binding to HSA is generally accurately determined, the binding sites to which a particular therapeutic agent binds are often unknown.
HSA Binding (binding) of
8) Confidence 0.41 Published 1995 Journal J Pharm Sci Section Abstract Doc Link 7500279 Disease Relevance 0.26 Pain Relevance 0.56
The influence of fatty acids on the binding of ketoprofen (KP), an NSAID, to HSA was examined by using a photoaffinity labeling technique.
HSA Binding (binding) of associated with cinod
9) Confidence 0.40 Published 2002 Journal Pharm. Res. Section Abstract Doc Link 12425462 Disease Relevance 0 Pain Relevance 0.10
CONCLUSION: Long-chain fatty acids regulate the binding properties of HSA in a complex manner, in which a simultaneous competitive and allosteric mechanism operates and which mainly involves domain I.


HSA Binding (binding) of
10) Confidence 0.40 Published 2002 Journal Pharm. Res. Section Body Doc Link 12425462 Disease Relevance 0 Pain Relevance 0
Our results show that binding to HSA is 99% at therapeutic levels.
HSA Binding (binding) of
11) Confidence 0.39 Published 1983 Journal Biochem. Pharmacol. Section Abstract Doc Link 6626262 Disease Relevance 0 Pain Relevance 0
Hydrophobic binding of these compounds to HSA at the warfarin site is possibly stabilized by the attraction of the delocalized negative charge to the basic lysine and arginine residues adjoining the lone tryptophan.
HSA Binding (binding) of
12) Confidence 0.39 Published 1988 Journal J Pharm Sci Section Abstract Doc Link 3373430 Disease Relevance 0.13 Pain Relevance 0.19
The interaction between human serum albumin (HSA) and fluoxetine hydrochloride (FLX) have been studied by using different spectroscopic techniques viz., fluorescence, UV-vis absorption, circular dichroism and FTIR under simulated physiological conditions.
HSA Binding (interaction) of associated with fluoxetine
13) Confidence 0.38 Published 2010 Journal Spectrochim Acta A Mol Biomol Spectrosc Section Abstract Doc Link 19932052 Disease Relevance 0 Pain Relevance 0.17
In the present work the interaction of meloxicam with HSA in aqueous solution at physiological pH has been investigated through circular dichroism and fluorescence spectroscopy.
HSA Binding (interaction) of
14) Confidence 0.38 Published 2010 Journal J Pharm Biomed Anal Section Abstract Doc Link 20089378 Disease Relevance 0.10 Pain Relevance 0.14
These results support the existence of distinct sites on HSA for reversible binding and hydrolysis of (R)-ketoprofen glucuronide.
HSA Binding (binding) of
15) Confidence 0.38 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7700262 Disease Relevance 0 Pain Relevance 0
The protein binding of the new nonsteroidal anti-inflammatory agent tolmetin to human serum albumin (HSA) and to the plasma of 8 healthy subjects was studied by equilibrium dialysis at 37 degrees and pH 7.4 with 14C-tolmetin.
HSA Binding (binding) of in plasma associated with inflammation
16) Confidence 0.37 Published 1978 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 710027 Disease Relevance 0.10 Pain Relevance 0.05
Non-steroidal anti-inflammatory drugs (NSAIDs) are strongly bound to human serum albumin (HSA), mainly to sites I and II.
HSA Binding (bound) of associated with inflammation and cinod
17) Confidence 0.37 Published 1996 Journal Chirality Section Abstract Doc Link 8777148 Disease Relevance 0.10 Pain Relevance 0.20
Human serum albumin (HSA), the major protein component in blood plasma and in extravascular spaces, is known to participate in the binding and transport of a variety of endogenous and exogenous organic compounds with anionic or electronegative features.
HSA Binding (binding) of in plasma
18) Confidence 0.37 Published 2010 Journal J. Struct. Biol. Section Abstract Doc Link 20347991 Disease Relevance 0 Pain Relevance 0.35
Five of 56 (8.9%) HD patients and 0 of 30 PD patients skin tested with a conjugate of human serum albumin (HSA) and EO had positive skin prick tests.
HSA Binding (conjugate) of in skin associated with renal failure
19) Confidence 0.36 Published 1984 Journal Clin. Nephrol. Section Abstract Doc Link 6467690 Disease Relevance 0.70 Pain Relevance 0.06
In relation to the photoallergic activity of this drug, the interaction of aceclofenac with human serum albumin (HSA) has been studied through fluorescence spectroscopy.
HSA Binding (interaction) of
20) Confidence 0.36 Published 2007 Journal Pharmazie Section Abstract Doc Link 17557739 Disease Relevance 0.23 Pain Relevance 0.10

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