INT185001

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.71
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CDH13) plasma membrane (CDH13) cytoplasm (CDH13)
CDH13 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 5 48.76 Quite Low
metalloproteinase 14 5.00 Very Low Very Low Very Low
Bioavailability 6 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
Opioid 4 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 66 99.32 Very High Very High Very High
Myeloid Leukemia 46 99.26 Very High Very High Very High
Breast Cancer 48 98.76 Very High Very High Very High
Cancer 289 98.00 Very High Very High Very High
Leukemia 21 95.28 Very High Very High Very High
Disease 21 93.56 High High
Targeted Disruption 1 91.16 High High
Recurrence 3 89.60 High High
Apoptosis 99 89.04 High High
Death 27 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thirteen of the analyzed loci showed statistically significant differences in DNA methylation when AD samples were compared to all NTL samples: OPCML, CDX2, HOXA1, CDKN2A EX2, SFRP1, CDH13, TWIST1, LZTS1, RASSF1, SFRP4 and 5, ESR1, and CDH1.
Gene_expression (samples) of CDH13 associated with adenocarcinoma
1) Confidence 0.46 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2206053 Disease Relevance 1.18 Pain Relevance 0
Up-regulation was also found for cadherin 13, a gene with growth inhibitory functions that is expressed in normal cells but not in the majority of human tumour cells of epithelial origin [61].
Neg (not) Gene_expression (expressed) of cadherin 13 associated with cancer
2) Confidence 0.35 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.55 Pain Relevance 0
Higher levels of methylation in multiple genes (NOR1, NPM2,OLIG2, HINI, SLC26A4) were found in patients with good prognosis AML, while no significant difference in methylation of p15, CDH13 and PGR was found between good and poor prognosis groups [Kroeger et al.
Gene_expression (methylation) of CDH13 associated with myeloid leukemia
3) Confidence 0.32 Published 2008 Journal Current Medicinal Chemistry Section Body Doc Link PMC2764862 Disease Relevance 1.00 Pain Relevance 0
Other genes, such as DCC and cadherin 13, were found overexpressed in our samples but underexpressed in other reports [34]; these genes probably have mutations that differentially affect their proteins.
Gene_expression (overexpressed) of cadherin 13
4) Confidence 0.24 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.99 Pain Relevance 0
Other genes, such as DCC and cadherin 13, were found overexpressed in our samples but underexpressed in other reports [34]; these genes probably have mutations that differentially affect their proteins.
Gene_expression (overexpressed) of cadherin 13
5) Confidence 0.21 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.99 Pain Relevance 0

General Comments

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