INT185004

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.77
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TFF3) proteinaceous extracellular matrix (TFF3) molecular_function (TFF3)
Anatomy Link Frequency
Caco-2 2
TFF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 5 19.08 Low Low
depression 2 16.56 Low Low
Neuropathic pain 2 15.60 Low Low
Inflammation 62 5.00 Very Low Very Low Very Low
psoriasis 6 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometrial Cancer 153 99.32 Very High Very High Very High
Cancer 291 97.92 Very High Very High Very High
Breast Cancer 52 84.48 Quite High
Apoptosis 36 79.48 Quite High
Congenital Anomalies 2 72.52 Quite High
Metastasis 14 70.88 Quite High
Carcinoma 63 68.84 Quite High
Aneuploidy 5 64.00 Quite High
Malignant Neoplastic Disease 22 62.72 Quite High
Adenocarcinoma 8 46.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A large number of multiple occurring differentially expressed transcripts were demonstrated in Caco-2, including intestinal trefoilfactor 3 (TFF3) and Aquaporin 3 (AQP3) among others.
Positive_regulation (demonstrated) of TFF3 in Caco-2
1) Confidence 0.47 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.34 Pain Relevance 0
A large number of multiple occurring differentially expressed transcripts were demonstrated in Caco-2, including intestinal trefoilfactor 3 (TFF3) and Aquaporin 3 (AQP3) among others.
Positive_regulation (demonstrated) of intestinal trefoilfactor 3 in Caco-2
2) Confidence 0.47 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.34 Pain Relevance 0
GATA3, ESR1, TFF1, TFF3 and ERBB4 were upregulated, whereas IGF2R, GATA6, EGFR and TGFA were downregulated in ER+ ERBB2-amplified tumors.
Positive_regulation (upregulated) of TFF3 associated with cancer
3) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.81 Pain Relevance 0
Intestinal trefoil protein, TFF3, AGR2 developmental gene, estrogen-regulated genes (MGB2, LTF, END1, MMP11), FOXA2, and MSX2 were significantly up-regulated in endometrioid endometrial carcinomas, while increased expression of FOLR, genes involved in the regulation of mitotic spindle checkpoint (STK15, BUB1, CCNB2), IGF2, PTGS1 and p16 were seen in non-endometrioid endometrial carcinomas.
Positive_regulation (regulated) of TFF3 associated with endometrial cancer
4) Confidence 0.34 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.33 Pain Relevance 0
Upregulated ESR1, GATA3, ERBB4, TFF1 and TFF3 gene expression was associated with ER+ ERBB2-amplified tumors.
Positive_regulation (Upregulated) of TFF3 gene associated with cancer
5) Confidence 0.16 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.95 Pain Relevance 0

General Comments

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