INT185005

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.75
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TOP2B) nucleoplasm (TOP2B) nucleolus (TOP2B)
chromosome (TOP2B) nucleus (TOP2B) enzyme binding (TOP2B)
Anatomy Link Frequency
band 2
TOP2B (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 63 99.52 Very High Very High Very High
cytokine 3 97.48 Very High Very High Very High
Inflammation 6 97.12 Very High Very High Very High
withdrawal 2 94.40 High High
Arthritis 5 90.88 High High
metalloproteinase 28 69.84 Quite High
methotrexate 5 5.00 Very Low Very Low Very Low
Paracetamol 3 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 63 99.52 Very High Very High Very High
Chromosome Aberrations 1 97.72 Very High Very High Very High
Leukemia 19 97.56 Very High Very High Very High
INFLAMMATION 7 97.12 Very High Very High Very High
Experimental Arthritis 1 91.92 High High
Apoptosis 15 89.00 High High
Cancer 37 76.92 Quite High
Skin Cancer 4 75.76 Quite High
Arthritis 5 68.84 Quite High
Autoimmune Disease 4 57.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In some cases, exposure to topoisomerase II poisons has been associated with the formation of specific types of leukemia that involve the MLL (mixed lineage leukemia) gene at chromosome band 11q23 or the chromosome 15;17 translocation that joins the PML (promyelocytic leukemia) and RARA (retinoic acid receptor ?)
Negative_regulation (exposure) of Gene_expression (poisons) of topoisomerase in band associated with leukemia
1) Confidence 0.41 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647315 Disease Relevance 0.47 Pain Relevance 0
The expression of Topoisomerase II (TOP2) was also repressed, confirming results obtained in NAC treated CHO cells [35].
Negative_regulation (repressed) of Gene_expression (expression) of Topoisomerase II
2) Confidence 0.15 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.16 Pain Relevance 0.15
A relation between TIMP-2 expression and topoisomerase II activity has also been suggested [25].
Negative_regulation (relation) of Gene_expression (expression) of topoisomerase II
3) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 1.12 Pain Relevance 0.42

General Comments

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