INT185017

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 4.84
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TOP2B) nucleoplasm (TOP2B) nucleolus (TOP2B)
chromosome (TOP2B) nucleus (TOP2B) enzyme binding (TOP2B)
Anatomy Link Frequency
cleavage 1
band 1
extracellular matrix 1
LoVo 1
TOP2B (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 49 99.04 Very High Very High Very High
rheumatoid arthritis 63 98.56 Very High Very High Very High
cytokine 3 96.52 Very High Very High Very High
Inflammation 12 96.16 Very High Very High Very High
withdrawal 2 94.40 High High
Arthritis 5 90.88 High High
cINOD 45 89.76 High High
Pain 2 86.72 High High
Somatostatin 6 83.00 Quite High
Enkephalin 9 82.44 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 9 100.00 Very High Very High Very High
Rheumatoid Arthritis 63 98.56 Very High Very High Very High
Leukemia 55 97.56 Very High Very High Very High
Chromosome Aberrations 3 97.24 Very High Very High Very High
INFLAMMATION 15 96.16 Very High Very High Very High
Cancer 156 92.28 High High
Experimental Arthritis 1 91.92 High High
Paraganglioma 105 88.56 High High
Apoptosis 107 88.52 High High
Malignant Neoplastic Disease 39 87.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of topoisomerase II?
Gene_expression (Expression) of topoisomerase
1) Confidence 0.75 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647315 Disease Relevance 0 Pain Relevance 0
Most likely, the specificity of topoisomerase II-mediated cleavage is determined by the local structure, flexibility, or malleability of the DNA that accompanies the sequence, as opposed to a direct recognition of the bases that comprise that sequence (69).
Gene_expression (cleavage) of topoisomerase II-mediated in cleavage
2) Confidence 0.65 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647315 Disease Relevance 0 Pain Relevance 0
In some cases, exposure to topoisomerase II poisons has been associated with the formation of specific types of leukemia that involve the MLL (mixed lineage leukemia) gene at chromosome band 11q23 or the chromosome 15;17 translocation that joins the PML (promyelocytic leukemia) and RARA (retinoic acid receptor ?)
Gene_expression (poisons) of topoisomerase in band associated with leukemia
3) Confidence 0.65 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2647315 Disease Relevance 0.47 Pain Relevance 0
The expression of Topoisomerase II (TOP2) was also repressed, confirming results obtained in NAC treated CHO cells [35].
Gene_expression (expression) of Topoisomerase II
4) Confidence 0.28 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.16 Pain Relevance 0.15
Although several markers such as immunohistochemical expression of the cell proliferation marker Ki-67/MIB-1, telomerase activity, hTERT expression, topoisomerase IIa expression, and mRNA expression of MMP-2 and EMMPRIN metalloproteinases have shown promising results, they need further evaluation.
Gene_expression (expression) of topoisomerase associated with metalloproteinase
5) Confidence 0.10 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1976114 Disease Relevance 0.99 Pain Relevance 0.18
The very low proliferation index (<1%) found in the presented case and the fact that no telomerase activity, hTERT expression, topoisomerase IIa expression, or mRNA expression of MMP-2 and EMMPRIN metalloproteinases was identified show the benign nature of this lesion.
Gene_expression (expression) of topoisomerase associated with metalloproteinase
6) Confidence 0.10 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1976114 Disease Relevance 0.47 Pain Relevance 0.21
No telomerase activity (TA), human telomerase reverse transcriptase expression (hTERT: telomerase catalytic subunit), topoisomerase IIa expression, or mRNA expression of matrix metalloproteinase (MMP)-2 and EMMPRIN (extracellular matrix metalloproteinase inducer) was detected.
Gene_expression (expression) of topoisomerase in extracellular matrix associated with metalloproteinase
7) Confidence 0.07 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC1976114 Disease Relevance 0.71 Pain Relevance 0.35
A relation between TIMP-2 expression and topoisomerase II activity has also been suggested [25].
Gene_expression (expression) of topoisomerase II
8) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 1.11 Pain Relevance 0.39
In particular, expression of BCRP-1, TYMS, ERCC1-2, and TOPO I was more than 9000-, 130-, 30- and 30-fold higher, respectively, in LoVo Dx cells than in the LoVo parental line.


Gene_expression (expression) of TOPO I in LoVo
9) Confidence 0.04 Published 2007 Journal J Transl Med Section Body Doc Link PMC2174440 Disease Relevance 0.75 Pain Relevance 0.39
One microgram of RNA was reverse-transcribed into cDNA using iScript (BioRad, Hercules, CA), according to the manufacturer's instructions, and analyzed by real-time RT-PCR (MyiQ System, BioRad) to detect the expression of human breast cancer-resistance protein (BCRP-1), excision repair cross-complementing 1 and 2 (ERCC1-2), topoisomerase I (TOPO I), and thymidylate synthase (TYMS) chemosensitivity markers.
Spec (analyzed) Gene_expression (expression) of TOPO I associated with breast cancer
10) Confidence 0.04 Published 2007 Journal J Transl Med Section Body Doc Link PMC2174440 Disease Relevance 0.18 Pain Relevance 0

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