INT185028

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.72
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IGF2) extracellular region (IGF2) carbohydrate metabolic process (IGF2)
IGF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 3 80.60 Quite High
withdrawal 2 57.00 Quite High
Inflammation 8 44.76 Quite Low
Central nervous system 4 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
psoriasis 3 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Enkephalin 1 5.00 Very Low Very Low Very Low
substance P 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosarcoma 2 97.40 Very High Very High Very High
Islet Cell Adenoma 8 92.96 High High
Hypoglycemia 38 90.96 High High
Gastrointestinal Stromal Tumor 54 89.52 High High
Cancer 41 84.32 Quite High
Metastasis 6 80.88 Quite High
Insulinoma 2 76.68 Quite High
Breast Cancer 2 61.04 Quite High
INFLAMMATION 9 44.76 Quite Low
Skin Cancer 4 38.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The association of "big" IGF II and NICTH was first identified by Daughaday in a patient with a fibrosarcoma [26].
IGF II Binding (association) of associated with fibrosarcoma
1) Confidence 0.46 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1781460 Disease Relevance 0.80 Pain Relevance 0
Compared to physiologic IGF II, it has a significantly higher affinity to the insulin receptor, and a lower affinity to its binding protein [24,25].
IGF II Binding (affinity) of
2) Confidence 0.36 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1781460 Disease Relevance 0.86 Pain Relevance 0
IGFB3 in turn has a major role in regulation of proliferation as a growth inhibitor through IGF2 binding and alternative IGF2 independent pathways [39].
IGF2 Binding (binding) of
3) Confidence 0.19 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.06 Pain Relevance 0.07
As the name implies, the mannose-6-phosphate/IGF2 receptor (M6P/IGR2R) is a bifunctional protein – it has distinct binding sites for mannose-6-phosphate and IGF2.
IGF2 Binding (binding) of
4) Confidence 0.12 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0 Pain Relevance 0

General Comments

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