INT18503

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Context Info
Confidence 0.27
First Reported 1990
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 10
Disease Relevance 6.21
Pain Relevance 1.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (SUMO1) nucleus (SUMO1) cytoplasm (SUMO1)
Anatomy Link Frequency
kidney 1
SUMO1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 9 97.12 Very High Very High Very High
Serotonin 5 96.88 Very High Very High Very High
agonist 20 96.16 Very High Very High Very High
antagonist 5 96.12 Very High Very High Very High
chemokine 44 5.00 Very Low Very Low Very Low
cytokine 20 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue 504 99.64 Very High Very High Very High
Hepatitis C Virus Infection 20 99.30 Very High Very High Very High
Infection 272 93.88 High High
Hepatitis 4 60.20 Quite High
Cytomegalovirus Infection 12 59.44 Quite High
Influenza Virus Infection 8 44.08 Quite Low
Equine Infectious Anemia 4 42.56 Quite Low
Disease 44 35.36 Quite Low
Fever 64 5.00 Very Low Very Low Very Low
Dengue Hemorrhagic Fever 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the minor component of [125I]PIC binding was similar to a site reported in kidney, having low affinities for all compounds tested, except guanabenz.
PIC Binding (binding) of in kidney
1) Confidence 0.27 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8263811 Disease Relevance 0 Pain Relevance 0.17
Guanosine 5'-(beta, gamma-imido)triphosphate greatly reduced the amount of [125I]PIC bound (greater than 80%), without changing the Kd of the residual binding.
PIC Binding (bound) of
2) Confidence 0.26 Published 1990 Journal Mol. Pharmacol. Section Abstract Doc Link 1974694 Disease Relevance 0 Pain Relevance 0.26
Competition for [3H]bromoxidine binding by PIC gave a Ki of 1.0 nM (nH = 1.0), whereas competition for [3H]yohimbine could be resolved into high and low affinity components, with Ki values of 3.7 and 84 nM, respectively.
PIC Binding (binding) of
3) Confidence 0.26 Published 1990 Journal Mol. Pharmacol. Section Abstract Doc Link 1974694 Disease Relevance 0 Pain Relevance 0.32
Epinephrine competition for [125I]PIC binding was stereoselective.
PIC Binding (binding) of
4) Confidence 0.26 Published 1990 Journal Mol. Pharmacol. Section Abstract Doc Link 1974694 Disease Relevance 0 Pain Relevance 0.32
Scatchard plots of specific [125I]PIC binding (0.1-5 nM) were linear, with a Kd of 1.2 +/- 0.1 nM. [125I]PIC bound to the same number of high affinity sites as the alpha 2-adrenergic receptor (alpha 2-AR) full agonist [3H] bromoxidine (UK14,304), which represented approximately 40% of the sites bound by the antagonist [3H]yohimbine.
PIC Binding (binding) of associated with antagonist and agonist
5) Confidence 0.26 Published 1990 Journal Mol. Pharmacol. Section Abstract Doc Link 1974694 Disease Relevance 0 Pain Relevance 0.18
Scatchard plots of specific [125I]PIC binding (0.1-5 nM) were linear, with a Kd of 1.2 +/- 0.1 nM. [125I]PIC bound to the same number of high affinity sites as the alpha 2-adrenergic receptor (alpha 2-AR) full agonist [3H] bromoxidine (UK14,304), which represented approximately 40% of the sites bound by the antagonist [3H]yohimbine.
PIC Binding (bound) of associated with antagonist and agonist
6) Confidence 0.26 Published 1990 Journal Mol. Pharmacol. Section Abstract Doc Link 1974694 Disease Relevance 0 Pain Relevance 0.22
In dengue, ubiquitin-proteasome genes have not been reported to be involved in the dengue virus life cycle although a recent publication has shown that dengue envelope protein interacts with SUMO-1 conjugating enzyme 9 (Ubc9) and that overexpression of Ubc9 reduces virus production in a cell line [44].
SUMO-1 Binding (conjugating) of associated with dengue
7) Confidence 0.07 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.38 Pain Relevance 0
In dengue, ubiquitin-proteasome genes have not been reported to be involved in the dengue virus life cycle although a recent publication has shown that dengue envelope protein interacts with SUMO-1 conjugating enzyme 9 (Ubc9) and that overexpression of Ubc9 reduces virus production in a cell line [44].
SUMO-1 Binding (interacts) of associated with dengue
8) Confidence 0.07 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.49 Pain Relevance 0
HCV polymerase has also been shown to interact with a ubiquitin-like protein leading to its degradation [43].
ubiquitin-like protein Binding (leading) of associated with hepatitis c virus infection
9) Confidence 0.07 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.67 Pain Relevance 0
HCV polymerase has also been shown to interact with a ubiquitin-like protein leading to its degradation [43].
ubiquitin-like protein Binding (interact) of associated with hepatitis c virus infection
10) Confidence 0.07 Published 2007 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2100376 Disease Relevance 1.67 Pain Relevance 0

General Comments

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