INT185035

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 6.50
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ERBB3) extracellular space (ERBB3) extracellular region (ERBB3)
plasma membrane (ERBB3) nucleus (ERBB3)
Anatomy Link Frequency
T-47D 1
SK-BR-3 1
Caco-2 1
UACC-893 1
MCF-7 1
ERBB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 11 73.84 Quite High
withdrawal 4 50.24 Quite High
Inflammation 4 38.00 Quite Low
antagonist 2 10.52 Low Low
imagery 21 5.00 Very Low Very Low Very Low
member 8 14 5.00 Very Low Very Low Very Low
Kinase C 7 5.00 Very Low Very Low Very Low
psoriasis 6 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Paracetamol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 284 100.00 Very High Very High Very High
Cancer 109 87.48 High High
Chromosome Aberrations 14 86.24 High High
Colorectal Cancer 2 86.04 High High
Leukemia 2 57.04 Quite High
Metastasis 4 56.96 Quite High
Disease 16 55.32 Quite High
Targeted Disruption 2 52.92 Quite High
INFLAMMATION 4 38.00 Quite Low
Skin Cancer 8 31.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, in correlation with the controversial results from NHEK, an up-regulation of ErbB3 was identified in Caco-2 at 12 hrs.
Regulation (regulation) of ErbB3 in Caco-2
1) Confidence 0.42 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.32 Pain Relevance 0
Surprisingly, ErbB3, which promotes proliferation through the Wnt signalling pathway, was also up-regulated.
Regulation (regulated) of ErbB3
2) Confidence 0.42 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1182358 Disease Relevance 0.20 Pain Relevance 0.06
Genetic, biochemical and pharmacologic studies of breast cancer have been greatly dependent on several commonly used model breast cancer cell lines: MCF-7, BT-474, SK-BR-3, T-47D, UACC-893, MDA-MB-231 and ZR-75-30.
Regulation (dependent) of MDA-MB-231 in T-47D associated with breast cancer
3) Confidence 0.34 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.86 Pain Relevance 0
Genetic, biochemical and pharmacologic studies of breast cancer have been greatly dependent on several commonly used model breast cancer cell lines: MCF-7, BT-474, SK-BR-3, T-47D, UACC-893, MDA-MB-231 and ZR-75-30.
Regulation (dependent) of MDA-MB-231 in BT-474 associated with breast cancer
4) Confidence 0.11 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.86 Pain Relevance 0
Genetic, biochemical and pharmacologic studies of breast cancer have been greatly dependent on several commonly used model breast cancer cell lines: MCF-7, BT-474, SK-BR-3, T-47D, UACC-893, MDA-MB-231 and ZR-75-30.
Regulation (dependent) of MDA-MB-231 in MCF-7 associated with breast cancer
5) Confidence 0.11 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.86 Pain Relevance 0
Genetic, biochemical and pharmacologic studies of breast cancer have been greatly dependent on several commonly used model breast cancer cell lines: MCF-7, BT-474, SK-BR-3, T-47D, UACC-893, MDA-MB-231 and ZR-75-30.
Regulation (dependent) of MDA-MB-231 in MDA-MB-231 associated with breast cancer
6) Confidence 0.11 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.86 Pain Relevance 0
Genetic, biochemical and pharmacologic studies of breast cancer have been greatly dependent on several commonly used model breast cancer cell lines: MCF-7, BT-474, SK-BR-3, T-47D, UACC-893, MDA-MB-231 and ZR-75-30.
Regulation (dependent) of MDA-MB-231 in ZR-75-30 associated with breast cancer
7) Confidence 0.11 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.86 Pain Relevance 0
Genetic, biochemical and pharmacologic studies of breast cancer have been greatly dependent on several commonly used model breast cancer cell lines: MCF-7, BT-474, SK-BR-3, T-47D, UACC-893, MDA-MB-231 and ZR-75-30.
Regulation (dependent) of MDA-MB-231 in UACC-893 associated with breast cancer
8) Confidence 0.11 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.86 Pain Relevance 0
Genetic, biochemical and pharmacologic studies of breast cancer have been greatly dependent on several commonly used model breast cancer cell lines: MCF-7, BT-474, SK-BR-3, T-47D, UACC-893, MDA-MB-231 and ZR-75-30.
Regulation (dependent) of MDA-MB-231 in SK-BR-3 associated with breast cancer
9) Confidence 0.11 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0.86 Pain Relevance 0

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