INT185047

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 1.65
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pln) protein complex (Pln)
Anatomy Link Frequency
muscle 3
myocardium 1
pancreas 1
popliteal lymph nodes 1
Th1 cells 1
Pln (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 15 87.44 High High
cytokine 76 81.00 Quite High
anesthesia 7 72.64 Quite High
Inflammation 15 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
Catecholamine 6 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypertrophy 45 99.54 Very High Very High Very High
Stress 31 95.04 Very High Very High Very High
Targeted Disruption 80 90.88 High High
Sprains And Strains 97 86.76 High High
Coronary Heart Disease 2 85.68 High High
Autoimmune Disease 16 80.72 Quite High
Hyperglycemia 4 70.64 Quite High
Disease 124 69.48 Quite High
Hypersensitivity 30 50.00 Quite Low
Diabetes Mellitus 25 44.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given that intracellular Ca2+ homeostasis is tightly regulated by a cascade of intracellular Ca2+ regulatory proteins including SERCA, phospholamban (PLB) and NCX [18], Western blot analysis was performed to evaluate the expression of SERCA2a, PLB and NCX.
Gene_expression (expression) of PLB
1) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.24 Pain Relevance 0
Our results shown in Fig. 5 revealed a significantly reduced expression of PLB associated with unchanged SERCA2a and NCX in myocardium from APP/PS1 mice compared with the WT group.
Gene_expression (expression) of PLB in myocardium
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 0.25 Pain Relevance 0
We showed that IL-2 neutralization prevents the differentiation of the CD8+ T cells in response to self-antigen cross-presentation in the pLN and their subsequent migration to the pancreas.
Gene_expression (presentation) of pLN in pancreas
3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0.15 Pain Relevance 0.08
Consistently, we observed that compared with endogenous pLN, Tx-pLN contained increased frequencies of DC expressing CD103+, which is indicative of their origin in the small intestinal lamina propria (Fig.
Gene_expression (contained) of pLN in lamina
4) Confidence 0.33 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2571923 Disease Relevance 0 Pain Relevance 0
Although contribution from regulatory T cells could not be excluded, this indicates that IL-10, which are secreted to a higher degree by Th2 than Th1 cells [45], in the PLN at this stage was produced mainly by Th2 cells.
Gene_expression (produced) of PLN in Th1 cells
5) Confidence 0.28 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.07 Pain Relevance 0.10
Of note, there was only an increase in PKB phosphorylation in the overloaded muscle with the altered recruitment pattern (PLN muscle).
Gene_expression (muscle) of PLN in muscle
6) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.22 Pain Relevance 0
Therefore, while the increased activation of PKB in the overloaded PLN muscle of the PTEN?
Gene_expression (muscle) of PLN in muscle
7) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.22 Pain Relevance 0
Ablation of the synergists induced a significant hypertrophy in all of the muscles analysed (PLN ?
Spec (analysed) Gene_expression (analysed) of PLN in muscles associated with hypertrophy
8) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905373 Disease Relevance 0.35 Pain Relevance 0
The popliteal lymph nodes (PLN) were excised five days after injection into both hind footpads of OVA and PSP, separately or in combination.
Gene_expression (excised) of PLN in popliteal lymph nodes
9) Confidence 0.24 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.14 Pain Relevance 0.11

General Comments

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