INT185049

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.84
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand1) nucleoplasm (Hand1) enzyme binding (Hand1)
DNA binding (Hand1) cytoplasm (Hand1) nucleolus (Hand1)
Anatomy Link Frequency
blood 1
cardiogenic 1
Th2 cells 1
regulatory T cells 1
Hand1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 86 100.00 Very High Very High Very High
chemokine 22 99.76 Very High Very High Very High
Inflammation 76 95.16 Very High Very High Very High
interstitial cystitis 41 90.08 High High
cva 1 11.52 Low Low
imagery 21 5.00 Very Low Very Low Very Low
Arthritis 15 5.00 Very Low Very Low Very Low
Action potential 11 5.00 Very Low Very Low Very Low
Crohn's disease 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cystitis 70 97.08 Very High Very High Very High
INFLAMMATION 77 95.16 Very High Very High Very High
Disease 39 94.40 High High
Interstitial Cystitis 41 90.08 High High
Infection 53 88.16 High High
Teratoma 10 82.12 Quite High
Sprains And Strains 92 81.92 Quite High
Death 8 78.44 Quite High
Hypersensitivity 29 62.24 Quite High
American Trypanosomiasis 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The description of the Th2/Th1 balance may explain parts of an immune response, however the immune regulation is more complex, involving other cytokines, cell surface molecules and regulatory T cells.
Transcription (description) of Th1 in regulatory T cells associated with cytokine
1) Confidence 0.47 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1182367 Disease Relevance 0.30 Pain Relevance 0.23
The ability of CXCL10 blockade to modulate local chemokines as well as Th1 cytokine mRNA expression and to facilitate the decline of serum levels of CXCL9 and CXCL10 is an indication of reduced local as well as systemic inflammation.
Transcription (expression) of Th1 associated with chemokine, inflammation and cytokine
2) Confidence 0.42 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2583981 Disease Relevance 0.75 Pain Relevance 0.36
In this study, we have identified twist1 as a gene that is differentially expressed by Th1 cells versus Th2 cells, comparing the transcriptomes of once and repeatedly restimulated murine Th1 and Th2 cells generated in vitro from bona fide naive Th cells.
Transcription (transcriptomes) of Th1 in Th2 cells
3) Confidence 0.34 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.18 Pain Relevance 0.09
The concentration of TH1 IL-12p40 was higher in the blood of Qro-infected mice than in Ninoa-infected mice.
Transcription (concentration) of TH1 in blood
4) Confidence 0.20 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.46 Pain Relevance 0.03
Differentiation into beating EBs was accompanied by mesodermal differentiation and dramatic activation of TWIST1, TBX5, and MEOX transcription, as well as the very clear induction of nearly all of the early cardiogenic genes, including FOXC1, ISL2, HAND1, GATA4, 5, and 6, FOXH1, and MEF2C.
Transcription (transcription) of HAND1 in cardiogenic
5) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565131 Disease Relevance 0.16 Pain Relevance 0

General Comments

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