INT18505

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Context Info
Confidence 0.57
First Reported 1990
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.90
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Coro1a) plasma membrane (Coro1a) cytoskeleton (Coro1a)
protein complex (Coro1a) cytoplasm (Coro1a)
Anatomy Link Frequency
lungs 1
Coro1a (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 100.00 Very High Very High Very High
Versed 1 99.88 Very High Very High Very High
Pain 1 87.76 High High
peripheral neuropathy 1 87.12 High High
dexamethasone 94 60.56 Quite High
Analgesic 1 25.00 Low Low
cytokine 9 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 7 100.00 Very High Very High Very High
Peripheral Neuropathy 1 87.12 High High
Pancreatitis 2 84.32 Quite High
Cancer 5 75.00 Quite High
Toxicity 1 75.00 Quite High
Repression 8 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Hypertrophy 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sixteen of 18 evaluable patients had a decrease in levels of human immunodeficiency virus p24 antigen by week 6 (P = .0034).
Negative_regulation (decrease) of human immunodeficiency virus associated with acquired immune deficiency syndrome or hiv infection
1) Confidence 0.57 Published 1990 Journal Rev. Infect. Dis. Section Abstract Doc Link 1974724 Disease Relevance 0.80 Pain Relevance 0.13
Several examples of well-documented clinically significant interactions include warfarin, oral contraceptives, cyclosporine, itraconazole, digoxin, verapamil, nifedipine, simvastatin, midazolam, and human immunodeficiency virus-related protease inhibitors.
Negative_regulation (inhibitors) of human immunodeficiency virus- associated with versed and acquired immune deficiency syndrome or hiv infection
2) Confidence 0.42 Published 2008 Journal Am. J. Med. Sci. Section Abstract Doc Link 18277121 Disease Relevance 0.10 Pain Relevance 0.05
In addition to increased expression of Sox17 (data not shown), mRNAs for the cyclin-dependent kinase inhibitors p15, p21, and p57 were significantly decreased in lungs of CCSPrtTA/tetO-Sox17 mice relative to CCSPrtTA controls following 1 day of exposure to Dox (Fig. 5).
Negative_regulation (decreased) of p57 in lungs
3) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0 Pain Relevance 0
Probes for Indian hedgehog (Ihh), Tissue inhibitor of matrix metalloproteinase 4 (Timp4), Cyclin-dependent kinase inhibitor 1C (Cdkn1c, p57), Integrin beta like 1 protein (Itgbl1), GC receptor (Nr3c1), Integrin beta 1 (Itgb1) and Kruppel-like factor 15 (Klf15) were assayed using the TaqMan® gene expression assays in accordance with the manufacturers directions.
Negative_regulation (inhibitor) of p57 associated with metalloproteinase
4) Confidence 0.03 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1929075 Disease Relevance 0 Pain Relevance 0.08

General Comments

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