INT18506

Context Info Confidence 0.57 First Reported 1989 Last Reported 1995 Negated 1 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 3.79 Pain Relevance 0.52

cell adhesion (CD9) plasma membrane (CD9)

Anatomy Link Frequency T-helper cell 1 CD9 (Homo sapiens)

Pain Link Frequency Relevance Heat abdominal pain 2 94.64 Pain 2 88.00 headache 1 87.88 peripheral neuropathy 2 87.36

Disease Link Frequency Relevance Heat Acquired Immune Deficiency Syndrome Or Hiv Infection 23 100.00 Abdominal Pain 2 94.64 Diarrhoea 2 93.72 Vomiting 2 93.32 Exanthema 1 93.00 Toxicity 3 90.04 Fatigue 1 88.24 Headache 1 87.88 Peripheral Neuropathy 2 87.36 Weight Gain 1 86.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There was no significant improvement in clinical state or T-helper cell levels, and no observed decrease in HIV p24 antigen during treatment.

Neg (no) Negative_regulation (decrease) of p24 in T-helper cell associated with acquired immune deficiency syndrome or hiv infection

1) Confidence 0.57 Published 1989 Journal J. Acquir. Immune Defic. Syndr. Section Abstract Doc Link 2493093 Disease Relevance 1.36 Pain Relevance 0.09

Sixteen of 18 evaluable patients had a decrease in levels of human immunodeficiency virus p24 antigen by week 6 (P = .0034).

Negative_regulation (decrease) of p24 associated with acquired immune deficiency syndrome or hiv infection

2) Confidence 0.42 Published 1990 Journal Rev. Infect. Dis. Section Abstract Doc Link 1974724 Disease Relevance 0.80 Pain Relevance 0.13

Sustained decreases in beta 2-microglobulin, neopterin, and p24 antigen levels were seen over the 52-week study.

Negative_regulation (decreases) of p24

3) Confidence 0.42 Published 1995 Journal J. Infect. Dis. Section Abstract Doc Link 7751691 Disease Relevance 0.60 Pain Relevance 0.18

The administration of ddI was associated with statistically significant decreases in serum level of p24 antigen and increases in the numbers of CD4 cells at 2, 6, 10, and 20 weeks.

Negative_regulation (decreases) of p24

4) Confidence 0.41 Published 1990 Journal N. Engl. J. Med. Section Abstract Doc Link 2139173 Disease Relevance 1.03 Pain Relevance 0.12

General Comments

This test has worked.