INT18513

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Context Info
Confidence 0.47
First Reported 1989
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 32
Total Number 34
Disease Relevance 9.44
Pain Relevance 15.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN1)
Anatomy Link Frequency
brain 2
spinal 2
neocortex 2
dendrites 1
postsynaptic membrane 1
GRIN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 200 100.00 Very High Very High Very High
ketamine 128 100.00 Very High Very High Very High
Dopamine 25 100.00 Very High Very High Very High
mu opioid receptor 10 100.00 Very High Very High Very High
MU agonist 4 100.00 Very High Very High Very High
Cannabinoid receptor 1 100.00 Very High Very High Very High
antagonist 68 99.96 Very High Very High Very High
Dextromethorphan 11 99.70 Very High Very High Very High
Glutamate receptor 62 99.64 Very High Very High Very High
Glutamate 127 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Post Operative Pain 4 99.24 Very High Very High Very High
Hyperalgesia 2 97.60 Very High Very High Very High
Status Epilepticus 67 97.04 Very High Very High Very High
INFLAMMATION 45 96.56 Very High Very High Very High
Convulsion 152 96.40 Very High Very High Very High
Depression 72 96.28 Very High Very High Very High
Cv General 4 Under Development 9 96.24 Very High Very High Very High
Poisoning 86 94.72 High High
Schizophrenia 22 94.64 High High
Sleep Disorders 94 94.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors show that xenon and isoflurane compete for the binding of the coagonist glycine on the NMDA receptor NR1 subunit.
NR1 Binding (binding) of associated with nmda receptor and isoflurane
1) Confidence 0.47 Published 2007 Journal Anesthesiology Section Abstract Doc Link 18073551 Disease Relevance 0 Pain Relevance 0.32
Functional interactions between dopamine D1-like receptors and NMDA subtype glutamate receptors have been implicated in the maintenance of normal brain activity and neurological dysfunction.
NMDA Binding (interactions) of in brain associated with anesthesia, dopamine and glutamate receptor
2) Confidence 0.47 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14762133 Disease Relevance 0 Pain Relevance 0.42
Understanding the molecular mechanisms by which D1 and NMDA receptors functionally interact may provide insight toward elucidating the molecular neurobiological mechanisms involved in many neuropsychiatric illnesses, such as schizophrenia.
NMDA Binding (interact) of associated with nmda receptor and schizophrenia
3) Confidence 0.47 Published 2004 Journal J. Neurosci. Section Abstract Doc Link 14762133 Disease Relevance 0.09 Pain Relevance 0.40
Frank Tortella and colleagues review the CNS pharmacology of dextromethorphan, its possible involvement with NMDA or sigma-receptors, and the potential clinical importance of this old 'new' drug.
NMDA Binding (involvement) of associated with dextromethorphan
4) Confidence 0.37 Published 1989 Journal Trends Pharmacol. Sci. Section Abstract Doc Link 2694543 Disease Relevance 0.32 Pain Relevance 0.57
GABAA, NMDA and cannabinoid receptor signalling
NMDA Binding (cannabinoid receptor) of associated with cannabinoid receptor
5) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873964 Disease Relevance 0.59 Pain Relevance 0.22
Indeed, ketamine interacts with NMDA-receptors involved in spinal neuroplasticity and hyperexcitability responsible for these phenomena.
NMDA Binding (interacts) of in spinal associated with ketamine and hyperexcitability
6) Confidence 0.36 Published 2010 Journal Rev Med Liege Section Abstract Doc Link 20222506 Disease Relevance 0.36 Pain Relevance 0.76
Glutamate plays a key role in the development of cerebral damage related to HIPP: it triggers the excitotoxic cascade by overactivating N-methyl-D-aspartate receptors (NMDA), implicated as important mediators of both learning and neuronal development.
NMDA Binding (overactivating) of in neuronal associated with glutamate and nmda receptor
7) Confidence 0.36 Published 2005 Journal J. Matern. Fetal. Neonatal. Med. Section Abstract Doc Link 16203600 Disease Relevance 0.26 Pain Relevance 0.31
The most extensively characterized, conantokin-G, is selective for subtypes of NMDA receptors containing the NR2B subunit.
NMDA Binding (subtypes) of associated with nmda receptor
8) Confidence 0.36 Published 2004 Journal Curr. Med. Chem. Section Abstract Doc Link 15579001 Disease Relevance 0.33 Pain Relevance 0.25
Because patients are usually exposed concomitantly to volatile anesthetics, we tested the hypothesis that volatile anesthetics interact with ketamine and/or Mg2+ at recombinantly expressed NMDA receptors.
NMDA Binding (interact) of associated with ketamine and nmda receptor
9) Confidence 0.36 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323344 Disease Relevance 0 Pain Relevance 0.39
Mg2+ and ketamine interact superadditively at N- methyl-D-aspartate (NMDA) receptors, which may explain the clinical efficacy of the combination.
NMDA Binding (interact) of associated with ketamine
10) Confidence 0.35 Published 2001 Journal Anesth. Analg. Section Abstract Doc Link 11323344 Disease Relevance 0 Pain Relevance 0.31
The SOL-1 homologues in rodents interact with kainate receptors [49] and NMDA receptors (NMDA-Rs) [50].
NMDA Binding (interact) of associated with nmda receptor
11) Confidence 0.35 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.18
The SOL-1 homologues in rodents interact with kainate receptors [49] and NMDA receptors (NMDA-Rs) [50].
NMDA Binding (interact) of associated with nmda receptor
12) Confidence 0.35 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0 Pain Relevance 0.18
Cell-based assay for antibodies binding human NMDAR
NMDAR Binding (binding) of
13) Confidence 0.34 Published 2010 Journal Brain Section Body Doc Link PMC2877907 Disease Relevance 0.29 Pain Relevance 0
To observe binding only to the extracellular domain of the NR1/NR2B, we did not permeabilize the cells and applied serum diluted 1:20 and CSF undiluted.
NR1 Binding (binding) of
14) Confidence 0.30 Published 2010 Journal Brain Section Body Doc Link PMC2877907 Disease Relevance 0 Pain Relevance 0
Fluorescent immunoprecipitation assay for antibodies to NMDAR
NMDAR Binding (assay) of
15) Confidence 0.30 Published 2010 Journal Brain Section Body Doc Link PMC2877907 Disease Relevance 0 Pain Relevance 0
Because eight of the cell-based assay scores were relatively low (1 or 1.5), including five negative by fluorescent immunoprecipitation assay, we re-analysed the binding to NMDAR (Supplementary Table 2).
NMDAR Spec (analysed) Binding (binding) of
16) Confidence 0.30 Published 2010 Journal Brain Section Body Doc Link PMC2877907 Disease Relevance 0.12 Pain Relevance 0
(A) NMDAR-antibody-positive CSF shows a hippocampal ‘neuropil’ binding pattern on rat brain sections.
NMDAR-antibody-positive Binding (binding) of in brain
17) Confidence 0.26 Published 2010 Journal Brain Section Body Doc Link PMC2877907 Disease Relevance 0.83 Pain Relevance 0.05
NR1-specific commercial antibodies (anti-NR1) precipitated large amounts of EGFP-NR1 which was not bound by NR2B-specific (anti-NR2B) or PSD95 (anti-PSD95) antibodies (data from three experiments).
EGFP-NR1 Neg (not) Binding (bound) of
18) Confidence 0.25 Published 2010 Journal Brain Section Body Doc Link PMC2877907 Disease Relevance 0.06 Pain Relevance 0
In the absence of exogenous glutamate and glycine, the rate of association of [3H]MK-801 with wild-type NR1-1a/NR2A receptors was considerably slower than that for [3H]dextrorphan.
NR1 Binding (association) of associated with glutamate
19) Confidence 0.13 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15992576 Disease Relevance 0 Pain Relevance 0.48
In contrast, NR1 residues, W611 and N812, were critical for specific binding of [3H]dextrorphan to NR1-1a/NR2A complexes with no corresponding influence on that of [3H]MK-801.
NR1 Binding (binding) of
20) Confidence 0.12 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15992576 Disease Relevance 0 Pain Relevance 0.39

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