INT185143

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Elane, Pik3r1) intracellular (Pik3r1) protein complex (Pik3r1)
cytosol (Pik3r1) peptidase activity (Elane) signal transduction (Pik3r1)
Anatomy Link Frequency
vein 1
Elane (Mus musculus)
Pik3r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 130 100.00 Very High Very High Very High
Kinase C 285 99.28 Very High Very High Very High
agonist 15 48.08 Quite Low
antagonist 20 5.00 Very Low Very Low Very Low
tetrodotoxin 15 5.00 Very Low Very Low Very Low
conotoxin 15 5.00 Very Low Very Low Very Low
Neurotransmitter 15 5.00 Very Low Very Low Very Low
Calcium channel 15 5.00 Very Low Very Low Very Low
potassium channel 5 5.00 Very Low Very Low Very Low
Action potential 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 50 5.00 Very Low Very Low Very Low
Overdose 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exogenous NE and clonidine activate PI3Ks
NE Positive_regulation (activate) of PI3K associated with clonidine
1) Confidence 0.01 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.10
To determine whether NE directly activates PI3Ks, we measured phosphorylation of Akt in control vein segments and in tissues incubated with exogenous NE (1 ?
NE Spec (whether) Positive_regulation (activates) of PI3K in vein
2) Confidence 0.01 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.15
As shown in Fig. 7B, stimulation with NE increased the amount of PI3P (reaction product), suggesting that NE activated PI3K?.
NE Positive_regulation (activated) of PI3K
3) Confidence 0.00 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.41
Since exogenous NE and clonidine activated PI3K?
NE Positive_regulation (activated) of PI3K associated with clonidine
4) Confidence 0.00 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.78
To test whether NE activates PI3K?
NE Spec (whether) Positive_regulation (activates) of PI3K
5) Confidence 0.00 Published 2005 Journal BMC Physiol Section Body Doc Link PMC1183225 Disease Relevance 0 Pain Relevance 0.29

General Comments

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