INT18515

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Context Info
Confidence 0.66
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 9.30
Pain Relevance 3.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Lipg) extracellular space (Lipg) extracellular region (Lipg)
molecular_function (Lipg)
Anatomy Link Frequency
blood 3
plasma 2
myocardium 1
pancreatic duct 1
soleus 1
Lipg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 10 100.00 Very High Very High Very High
Cannabinoid 5 100.00 Very High Very High Very High
Kinase C 1 100.00 Very High Very High Very High
withdrawal 9 98.40 Very High Very High Very High
analgesia 5 98.24 Very High Very High Very High
Sciatic nerve 33 97.16 Very High Very High Very High
qutenza 8 96.24 Very High Very High Very High
anesthesia 3 95.76 Very High Very High Very High
ischemia 31 93.28 High High
bradykinin 6 92.84 High High
Disease Link Frequency Relevance Heat
Pancreatitis 121 99.74 Very High Very High Very High
Cancer 8 99.68 Very High Very High Very High
Injury 31 99.60 Very High Very High Very High
Sprains And Strains 26 99.46 Very High Very High Very High
Necrosis 14 99.44 Very High Very High Very High
Death 23 99.16 Very High Very High Very High
Nervous System Injury 19 98.96 Very High Very High Very High
Exocrine Pancreatic Insufficiency 1 97.80 Very High Very High Very High
Diabetes Mellitus 4 96.00 Very High Very High Very High
Cv Unclassified Under Development 14 93.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ischemic preconditioning, applied prior to induction of pancreatitis, caused the reduction in plasma lipase, plasma interleukin-1beta and histological signs of pancreatic damage, as well as attenuated the reduction in pancreatic blood flow and DNA synthesis.
Gene_expression (reduction) of plasma lipase in blood associated with pancreatitis
1) Confidence 0.66 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12892840 Disease Relevance 0.94 Pain Relevance 0.43
This is consistent with our results: The EDL consisted of 40 and the soleus of 30 motor units in all age groups.
Gene_expression (consisted) of EDL in soleus
2) Confidence 0.58 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC522819 Disease Relevance 0.50 Pain Relevance 0.09
Figure 2, images the different single twitch tension recordings, elicite, in an EDL muscle on the left leg (side of nerve injury), after stimulation of the left sciatic nerve with electrical stimuli of incrementally increasing intensity.
Gene_expression (muscle) of EDL in sciatic nerve associated with nervous system injury and sciatic nerve
3) Confidence 0.58 Published 2004 Journal BMC Musculoskelet Disord Section Body Doc Link PMC522819 Disease Relevance 0.18 Pain Relevance 0.05
Further, an intraduodenal injection of fatty acid (linoleic acid) moderately suppressed ASNA and significantly stimulated GVNA; these results indicate that fat may affect autonomic nerve activity partly through the chemoreception of free fatty acids (FFAs), which are produced during the hydrolysis of fat (corn oil) by a pancreatic lipase, in the intestinal lumen.
Gene_expression (produced) of lipase in intestinal lumen
4) Confidence 0.58 Published 2010 Journal Neurosci. Res. Section Abstract Doc Link 20362017 Disease Relevance 0 Pain Relevance 0
RESULTS: Ischemia followed by 1 h reperfusion led to induction of necrotizing pancreatitis, manifested by morphological signs of pancreatic damage, decrease in pancreatic DNA synthesis and PBF, as well as an increase in plasma amylase and lipase activity and plasma IL-1beta concentration.
Gene_expression (concentration) of lipase in plasma
5) Confidence 0.47 Published 2003 Journal Med. Sci. Monit. Section Body Doc Link 14646970 Disease Relevance 0.13 Pain Relevance 0
There were transient changes in serum insulin and lipase levels, but the significance of these findings are not clear.
Gene_expression (levels) of lipase
6) Confidence 0.43 Published 2000 Journal Int. J. Pancreatol. Section Abstract Doc Link 10952402 Disease Relevance 0.76 Pain Relevance 0.17
Amylase, trypsinogen, chymotrypsinogen and lipase synthesis, and amylase secretion were measured for 2 hr.
Gene_expression (synthesis) of lipase
7) Confidence 0.36 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 7525167 Disease Relevance 0.34 Pain Relevance 0.46
The EDL and myocardium removed from these animals were used exclusively for the investigation of changes in protein and phosphorylation levels of translation initiation signalling events.


Gene_expression (used) of EDL in myocardium
8) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.14 Pain Relevance 0
The carbachol inhibition of evoked IPSCs was reduced by the cannabinoid CB(1) receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide) and the diacylglycerol (DAG) lipase inhibitor tetrahydrolipstatin, and it was abolished in the presence of both AM251 and gallamine.
Gene_expression (reduced) of lipase associated with antagonist and cannabinoid
9) Confidence 0.25 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18678620 Disease Relevance 0.56 Pain Relevance 0.85
This was accompanied by the reduction of serum lipase, and TNFalpha activities.
Gene_expression (reduction) of serum lipase
10) Confidence 0.25 Published 2009 Journal Growth Horm. IGF Res. Section Abstract Doc Link 19615927 Disease Relevance 0.82 Pain Relevance 0.20
The levels of blood sugar, lipase, serum tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), ghrelin, and leptin were investigated and histopathologic examination was performed.
Spec (investigated) Gene_expression (levels) of lipase in blood associated with necrosis and cancer
11) Confidence 0.22 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17333355 Disease Relevance 1.19 Pain Relevance 0.18
RESULTS: CIP was manifested by an increase in plasma levels of amylase, lipase, leptin and an anti-inflammatory interleukin 10 (IL-10), (by 400%, 1000%, 700% and 50%, respectively), confirmed by histological examination and accompanied by 40% reduction in pancreatic blood flow.
Gene_expression (levels) of lipase in blood
12) Confidence 0.21 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 11951059 Disease Relevance 0.17 Pain Relevance 0
Serum amylase, lipase and CRP were significantly reduced in all treated groups.
Gene_expression (reduced) of lipase
13) Confidence 0.20 Published 2003 Journal Pancreatology Section Body Doc Link 14631103 Disease Relevance 0 Pain Relevance 0
These data suggest Ca2+ influx is required for ligand-stimulated accumulation of both arachidonate (a product of diglyceride-lipase or phospholipase A2) and diglyceride (a product of phospholipase C).
Gene_expression (product) of diglyceride-lipase
14) Confidence 0.18 Published 1990 Journal Brain Res. Section Abstract Doc Link 1975211 Disease Relevance 0.15 Pain Relevance 0.43
Indeed, microglial cells express both fatty acid amide hydrolase and monoacylglycerol lipase, as well as other activities including a PEA hydrolase with a distinct pharmacological profile [22].
Gene_expression (express) of lipase in microglial cells
15) Confidence 0.16 Published 2009 Journal Mol Pain Section Body Doc Link PMC2719614 Disease Relevance 0.56 Pain Relevance 0.30
This coincided with declining lipase levels.
Gene_expression (levels) of lipase
16) Confidence 0.09 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1988801 Disease Relevance 0.37 Pain Relevance 0.10
Lactococcus lactis strains genetically engineered to produce lipase have been shown to be capable of alleviating a lipase pancreatic insufficiency caused by ligation of the pancreatic duct in pigs [20].
Gene_expression (produce) of lipase in pancreatic duct associated with exocrine pancreatic insufficiency and sprains and strains
17) Confidence 0.07 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2270848 Disease Relevance 0.38 Pain Relevance 0
Resveratrol did not affect lipase activity, concentrations of IL-1ß and IL-10 in the plasma as well as pancreatic DNA synthesis.
Gene_expression (activity) of lipase in plasma
18) Confidence 0.07 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872306 Disease Relevance 1.15 Pain Relevance 0.06
Evidence is gathering that a various of factors induced over-accumulation of intracellular calcium triggers proteases, lipase, protein kinase C, nitric oxide synthase, endonucleases, altered gene transcription, and release of free radicals, eventually producing neuronal injury and death.
Gene_expression (producing) of lipase in neuronal associated with kinase c, injury and death
19) Confidence 0.01 Published 2002 Journal BMC Neurol Section Body Doc Link PMC107739 Disease Relevance 0.95 Pain Relevance 0.41

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