INT18518

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Context Info
Confidence 0.60
First Reported 1988
Last Reported 2007
Negated 2
Speculated 2
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 0
Pain Relevance 3.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Anatomy Link Frequency
neurons 2
brain 2
pituitary 2
hippocampus 2
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 29 100.00 Very High Very High Very High
Serotonin 14 99.98 Very High Very High Very High
Enkephalin 8 99.74 Very High Very High Very High
Dopamine 2 99.66 Very High Very High Very High
MU agonist 8 99.60 Very High Very High Very High
antagonist 3 99.44 Very High Very High Very High
Hippocampus 12 98.64 Very High Very High Very High
Nucleus accumbens 4 93.80 High High
withdrawal 4 89.48 High High
Dynorphin 13 87.40 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Striatal c-fos induction was blocked by local administration of phosphorothioated c-fos antisense oligonucleotides (AS-ODN) to examine the possible role of caffeine-induced c-fos expression in transcriptional regulation of striatal preproenkephalin, prodynorphin, preprotachykinin A and neurotensin/neuromedin N.
Spec (possible) Regulation (role) of Regulation (regulation) of prodynorphin
1) Confidence 0.60 Published 1997 Journal Eur. J. Neurosci. Section Abstract Doc Link 9421173 Disease Relevance 0 Pain Relevance 0
Our data suggest hormonal regulation of cocaine effects on PDYN mRNA levels which may modulate cocaine-induced behaviors in female rats.
Regulation (regulation) of Regulation (effects) of PDYN mRNA associated with cocaine
2) Confidence 0.58 Published 2002 Journal Brain Res. Bull. Section Abstract Doc Link 12128156 Disease Relevance 0 Pain Relevance 0.39
The effect of L-arginine (L-ARG), a nitric oxide donor, or Nomega-nitro-L-arginine (L-NAME), a nitric oxide synthase inhibitor, on the regulation of kainic acid (KA)-induced proenkephalin (proENK) and prodynorphin (proDYN) mRNA expressions in rat hippocampus was studied.
Regulation (effect) of Regulation (regulation) of prodynorphin in hippocampus associated with hippocampus
3) Confidence 0.44 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9602069 Disease Relevance 0 Pain Relevance 0.09
On the other hand, acute ethanol had no effect on the POMC and PDYN mRNA levels, nor did it affect the alpha-neoendorphin concentration in the pituitary.
Neg (nor) Regulation (affect) of Neg (nor) Regulation (affect) of alpha-neoendorphin in pituitary
4) Confidence 0.42 Published 1994 Journal Neuroendocrinology Section Abstract Doc Link 7969792 Disease Relevance 0 Pain Relevance 0.22
To determine whether serotonin plays a role in the regulation of prodynorphin mRNA by kappa-opioid agonists or cocaine, rats were treated with the serotonin depleter parachloroamphetamine (PCA).
Spec (whether) Regulation (plays) of Spec (whether) Regulation (regulation) of prodynorphin mRNA associated with mu agonist, serotonin and cocaine
5) Confidence 0.27 Published 2007 Journal Neuroscience Section Abstract Doc Link 17055175 Disease Relevance 0 Pain Relevance 1.15
Dopaminergic regulation of striatal proenkephalin mRNA and prodynorphin mRNA: contrasting effects of D1 and D2 antagonists.
Regulation (effects) of Regulation (regulation) of prodynorphin mRNA associated with antagonist and enkephalin
6) Confidence 0.27 Published 1988 Journal Neuroscience Section Title Doc Link 3041310 Disease Relevance 0 Pain Relevance 0.35
Subsequent to PCA administration the effects of U-69593 or cocaine on prodynorphin mRNA were differentially affected across brain regions.
Regulation (affected) of Regulation (effects) of prodynorphin mRNA in brain associated with cocaine
7) Confidence 0.24 Published 2007 Journal Neuroscience Section Abstract Doc Link 17055175 Disease Relevance 0 Pain Relevance 1.13
The relatively subtle effects of HAL on prodynorphin peptides suggests that tonic dopamine activity is not important in the regulation of striatonigral prodynorphin neurons.
Neg (not) Regulation (important) of Regulation (regulation) of prodynorphin in neurons associated with dopamine
8) Confidence 0.15 Published 1990 Journal Brain Res. Section Abstract Doc Link 1975215 Disease Relevance 0 Pain Relevance 0.26

General Comments

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